{"product_id":"abcam-ab132656","title":"Abcam, ab132656, Recombinant Human OAS2 protein","description":"\u003cp\u003eSize: 2µg \/ 10µg\u003cbr\u003e\nRecombinant Human OAS2 protein is a Human Full Length protein, in the 1 to 687 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:ELISA, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P29728,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOligoadenylate synthetase 2 (OAS2) is also known as OAS2A and OAS2LLC. It belongs to the 2'-5' oligoadenylate synthase family and possesses a mass of approximately 71 kDa. OAS2 is expressed in various tissues with higher levels noted in the liver and immune cells. Its mechanical function involves the synthesis of 2'-5' linked oligoadenylates (2-5A) upon activation by double-stranded RNA a byproduct of viral infections signalling for the degradation of viral RNA.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOAS2 is essential in the innate immune response against viral infections. It forms part of a protein complex that activates RNase L an enzyme responsible for degrading viral and cellular RNA thereby limiting viral replication. By doing this OAS2 helps control viral proliferation during the early phases of infection contributing to the host's antiviral defense mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nOAS2 functions in the antiviral pathway related to the innate immune response. It closely associates with the interferon signaling pathway initiating a cascade of reactions that enhance the immune response. RNase L and OAS1 are important proteins related to OAS2 in this pathway. Both proteins synergistically work to recognize and respond to viral infections ensuring an effective and timely immune response.\u003cbr\u003e\nResearchers have linked OAS2 to diseases such as viral hepatitis and autoimmune disorders like SLE (Systemic Lupus Erythematosus). In viral hepatitis OAS2 plays a role in limiting the replication of hepatitis viruses and studies have observed its interaction with proteins like interleukin-6 (IL-6) within the context of SLE. The aberrant activation or regulation of OAS2 might contribute to disease pathogenesis or severity making it a potential target for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843874705577,"sku":"ab132656","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab132656","provider":"Iright","version":"1.0","type":"link"}