{"product_id":"abcam-ab132722","title":"Abcam, ab132722, Recombinant Human SDCCAG8 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human SDCCAG8 protein is a Human Full Length protein, in the 1 to 360 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q86SQ7,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSDCCAG8 also known as Serologically Defined Colon Cancer Antigen 8 is a protein weighing approximately 92 kDa. This protein localizes primarily to centrosomes and cilia within the cell. SDCCAG8 gets expressed in many tissues with notable expression in the ciliated cells of the respiratory tract. The protein plays roles in centrosomal organization and the regulation of cilia formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein has key roles in cell division and ciliogenesis due to its interaction with other proteins involved in these processes. SDCCAG8 is part of a protein complex that is important for stabilizing centrosomes and promoting proper ciliogenesis. It interacts with centriolar proteins affecting cellular structure and function. Through these interactions SDCCAG8 supports cell cycle progression and normal cellular signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nSDCCAG8 participates in the centrosome-cilium interface impacting cell division and signaling pathways such as Wnt and Hedgehog. SDCCAG8 collaborates with proteins like OFD1 and CEP290 which contribute to the integrity of these pathways. These associations ensure accurate cellular signaling and distribution of cellular components during mitosis.\u003cbr\u003e\nSDCCAG8 mutations have been linked to disorders such as Bardet-Biedl syndrome and related ciliopathies. These diseases often involve symptoms like retinal degeneration and polydactyly. The protein's association with others like BBS4 and BBS1 highlights its involvement in the pathological mechanisms of these conditions by affecting the structure and signaling capacity of cilia.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843882504361,"sku":"ab132722","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab132722","provider":"Iright","version":"1.0","type":"link"}