{"product_id":"abcam-ab134921","title":"Abcam, ab134921, Anti-Tat-SF1 antibody [EPR9105(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HTSF1 antibody. Suitable for WB, IP, ICC\/IF, IHC-P and reacts with Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9105(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTat-SF1 also known as transcription elongation factor SPT5 (SPT4-5) is a protein integral to the RNA transcription process. The mass of Tat-SF1 is approximately 90 kDa. It is primarily expressed in the nucleus of the cell where it interacts with RNA Polymerase II to facilitate the elongation phase of transcription. Tat-SF1 plays a significant role by enhancing the transcriptional speed and efficiency critical for the production of various RNA species.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTat-SF1 functions by participating in the regulation of transcription elongation. It is part of the larger multi-protein complex involving CycT1 another important transcription factor. This complex helps modulate the interaction of RNA polymerase II with other transcriptional machinery and influences the synthesis of mRNA. Through these actions Tat-SF1 supports the accurate gene expression important for normal cellular processes and response to environmental cues.\u003cbr\u003e\nPathways\u003cbr\u003e\nTat-SF1 has functions within the general transcriptional regulation pathway and the HIV-1 viral transcription pathway. It directly interacts with the HIV-1 Tat protein; this interaction is essential for efficient transcription of HIV-1 genes. The connection with the CycT1 protein is important within these pathways as it aids in recruiting Tat-SF1 to the sites where RNA polymerase II needs support therefore coordinating a precise transcriptional response.\u003cbr\u003e\nTat-SF1 is notably linked to HIV-1 infection due to its interaction with the viral Tat protein facilitating viral replication. Disruption or alteration in the function of Tat-SF1 can hinder this process making it a target for therapeutic interventions. Additionally any dysregulation in the normal transcriptional process involving Tat-SF1 and CycT1 can contribute to oncogenesis as improper gene expression can lead to unregulated cell proliferation. Understanding these connections highlights the importance of Tat-SF1 in disease mechanisms and therapeutic strategy development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850359230633,"sku":"ab134921","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab134921","provider":"Iright","version":"1.0","type":"link"}