{"product_id":"abcam-ab137074","title":"Abcam, ab137074, Anti-Ube4a antibody [EPR7332]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal UBE4A antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7332,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUbe4a also known as U-box containing E3 ubiquitin protein ligase 4A plays a role in the ubiquitination process. It catalyzes the transfer of ubiquitin molecules to specific substrates tagging them for degradation by the proteasome. Ube4a has an approximate molecular mass of 121 kDa. Researchers have observed its expression in various tissues indicating a potential role in widespread cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUbe4a functions in the regulation of protein quality and turnover. It forms part of a ubiquitin-proteasome system playing an important role in maintaining protein homeostasis within cells. The regulation of protein levels is important for various cellular processes including cell cycle control and signal transduction. Ube4a engages in multi-subunit complexes interacting with other E3 ligases to facilitate substrate ubiquitination.\u003cbr\u003e\nPathways\u003cbr\u003e\nUbe4a integrates into the ubiquitin-proteasome pathway a central component in protein degradation. This pathway is essential for regulating various cellular processes including responses to stress. Ube4a works alongside E1 activating enzymes and E2 conjugating enzymes to deliver ubiquitin to substrates efficiently. Its role within this pathway emphasizes the modulation of protein function and turnover linking it with other proteins like USP5 and UCH37 which are involved in deubiquitination.\u003cbr\u003e\nUbe4a associates with certain neurological conditions and cancer. Researchers have linked aberrant ubiquitination to the pathology of these diseases indicating the importance of Ube4a in maintaining cellular balance. In neurodegenerative disorders improper Ube4a activity may disrupt protein degradation implicating proteins like Parkin. In some cancer types altered Ube4a expression can affect cell cycle regulation with downstream impacts on other proteins such as p53 highlighting its potential involvement in tumorigenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855721418921,"sku":"ab137074","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab137074","provider":"Iright","version":"1.0","type":"link"}