{"product_id":"abcam-ab137193","title":"Abcam, ab137193, Anti-NRL antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal NRL antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NRL.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human NRL. The exact immunogen used to generate this antibody is proprietary information.P54845\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNRL also known as Neural Retina Leucine zipper is a transcription factor weighing approximately 27 kDa. It plays a mechanical role in the regulation of gene expression specific to the retina. Predominantly expressed in the photoreceptor cells of the retina NRL is important for the development and maintenance of these cells. Its expression is tightly controlled during retinal differentiation particularly in rod photoreceptors where it dictates cellular development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNRL acts as an important regulator in photoreceptor cell differentiation and function. It forms complexes with other transcription factors such as CRX and NR2E3 to activate transcription of rod-specific genes. These complexes are important for the expression of genes necessary for phototransduction the process by which light is converted into electrical signals in the eyes. NRL's interactions target important retinal genes establishing its role as a determinant for rod versus cone cell fates.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of NRL is integrated into the phototransduction and retinoid metabolism pathways. Within these pathways NRL cooperates with other proteins like CRX and NR2E3 to control the expression of genes needed for rod photoreceptor function. NRL's orchestration of gene expression in these pathways assures the successful transduction of light signals and vitamin A recycling which are reactions critical for vision.\u003cbr\u003e\nMutations or dysfunctions in NRL are connected to retinal degenerative diseases like retinitis pigmentosa and Leber congenital amaurosis. In these conditions NRL's aberrant activity disrupts proper photoreceptor development leading to visual impairment. NRL's interactions with proteins such as CRX in these diseases are pivotal as mutations affecting these proteins also contribute to the pathogenesis highlighting the tight regulation required for correct retinal function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850117271721,"sku":"ab137193","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab137193","provider":"Iright","version":"1.0","type":"link"}