{"product_id":"abcam-ab137583","title":"Abcam, ab137583, Anti-SEC23A antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal SEC23A antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Protein transport protein Sec23A aa 100-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Protein transport protein Sec23A aa 100-450. The exact immunogen used to generate this antibody is proprietary information.Q15436\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSEC23A also known as Sar1p interaction protein is a component of the COPII-coated vesicle complex responsible for transport from the endoplasmic reticulum (ER) to the Golgi apparatus. With a mass of approximately 85 kDa SEC23A plays a mechanical role in vesicle formation by promoting coat complex assembly which is critical for cargo selection. This protein is expressed ubiquitously in various tissues especially in those with high secretory demands such as pancreas and liver.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSEC23A functions as part of the COPII complex a group essential for vesicle budding from the ER. The interaction of SEC23A with other COPII components such as SEC24 allows it to select and package secretory proteins efficiently. This activity is not only important for protein trafficking but also for maintaining ER homeostasis and cellular function. Its certain role in the secretion pathway highlights the importance of proper protein sorting in cell and tissue health.\u003cbr\u003e\nPathways\u003cbr\u003e\nSEC23A is an important player in the secretory pathway particularly involved in COPII-mediated vesicular transport. It interacts closely with SEC24 and Sar1 facilitating the transition of proteins through the early secretory pathway. Additionally SEC23A engages with lipid-related pathways contributing to lipid metabolism and transport ensuring the precise delivery of lipid-related proteins across organelles.\u003cbr\u003e\nMutations in SEC23A associate with cranio-lenticulo-sutural dysplasia (CLSD) a condition marked by skeletal and craniofacial abnormalities. This disorder is linked to the disruption in protein and collagen export due to impaired COPII function involving interactions between SEC23A and SEC24. Furthermore SEC23A is related to pancreatic disorders where dysfunction in COPII-mediated trafficking can lead to improper protein secretion and cellular stress affecting proteins such as insulin and digestive enzymes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854170706089,"sku":"ab137583","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab137583","provider":"Iright","version":"1.0","type":"link"}