{"product_id":"abcam-ab137611","title":"Abcam, ab137611, Anti-TXNDC4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TXNDC4 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ERP44 aa 200 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ERP44 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BS26\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTXNDC4 also known as ERp46 or thioredoxin domain-containing protein 4 is an enzyme involved in protein folding within the endoplasmic reticulum. With a molecular mass of approximately 47 kDa this protein exhibits oxidoreductase activity and facilitates the formation and isomerization of disulfide bonds in nascent proteins. TXNDC4 is widely expressed across various tissues with a higher presence in the liver and pancreas reflecting its significant role in protein maturation and quality control processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTXNDC4 influences various cellular mechanisms by maintaining redox homeostasis and promoting the correct folding of proteins. It functions as part of a multi-protein complex interacting with other chaperones and co-chaperones within the endoplasmic reticulum. These interactions are critical for efficient protein maturation preventing the accumulation of misfolded proteins and thereby avoiding cellular stress. TXNDC4 is essential for maintaining the functional integrity of secretory pathways which support numerous cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nTXNDC4 plays a role in the unfolded protein response (UPR) and the oxidative folding pathway. The protein interacts closely with components such as protein disulfide isomerase (PDI) and ER oxidoreductin 1 (Ero1) within these pathways. Together these proteins facilitate efficient protein folding and prevent overaccumulation of unfolded proteins. The activity of TXNDC4 also relates to the regulation of cellular redox conditions which are pivotal for maintaining cellular homeostasis and proper response to stress.\u003cbr\u003e\nResearch indicates a connection between TXNDC4 and several conditions such as cancer and diabetes. Abnormal expression or malfunction of TXNDC4 can contribute to improper protein folding which may lead to unfolded protein response activation enhancing cellular stress conditions associated with these disorders. In cancer interactions between TXNDC4 and other proteins like Ero1α can alter redox balance affecting cell proliferation and survival. In diabetes improper protein processing in insulin-secreting cells may involve TXNDC4 dysfunction impacting insulin secretion and cellular homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850155806889,"sku":"ab137611","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab137611","provider":"Iright","version":"1.0","type":"link"}