{"product_id":"abcam-ab137869","title":"Abcam, ab137869, Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) is a rabbit monoclonal antibody detecting Tyrosine Hydroxylase in  Western Blot, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 60 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP1532Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC\/IF, IHC-P and WB.\u003cbr\u003e\nAnti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) was first used in a scientific publication in 2016 and has been cited over 69 times in peer reviewed journals. It's performance in Western Blot in mouse samples is trusted by the scientific community.\u003cbr\u003e\nAbcam's high quality manufacturing and validation processes ensure Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nAnti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) has 9 independent reviews from customers.\u003cbr\u003e\nAnti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) specifically detects Tyrosine Hydroxylase (UniProt ID: P07101; Molecular weight: 59kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL).\u003cbr\u003e\nConjugation-ready, carrier free format available for antibody clone EP1532Y -\u003cbr\u003e\nab220218\u003cbr\u003e\nAntibody clone EP1532Y is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor\u003cbr\u003e\n488, Alexa Fluor\u003cbr\u003e\n568, Alexa Fluor\u003cbr\u003e\n555, APC, PE, Alexa Fluor\u003cbr\u003e\n647, Alexa Fluor\u003cbr\u003e\n594, Alexa Fluor\u003cbr\u003e\nab207673\u003cbr\u003e\nab302827\u003cbr\u003e\nab302968\u003cbr\u003e\nab305365\u003cbr\u003e\nab310825\u003cbr\u003e\nab310901\u003cbr\u003e\nab311092\u003cbr\u003e\nab311693\u003cbr\u003e\nab321111\u003cbr\u003e\nNEW: Explore our alternative host species for clone EP1532Y : goat, mouse, chicken. Tyrosine hydroxylase (TH) is a critical enzyme in neuro research, particularly for its role in the synthesis of catecholamines, including dopamine, norepinephrine and epinephrine. It is a key marker for identifying dopaminergic neurons in the central nervous system. Researchers use tyrosine hydroxylase to study the regulation of neurotransmitter production and its implications in neurological disorders such as Parkinson's disease (PD) and tyrosine hydroxylase deficiency. Its expression helps in understanding the biochemical pathways involved in neurodegenerative diseases and the development of potential therapeutic strategies.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTyrosine hydroxylase also known as TH is an enzyme that catalyzes the conversion of L-tyrosine to L-DOPA. It weighs approximately 60 kDa. You can find this enzyme expressed mainly in the brain adrenal glands and some peripheral tissues. Commonly studied antibodies include anti-tyrosine hydroxylase or anti-TH. It plays a significant role in the catecholamine biosynthesis pathway serving as the rate-limiting step in dopamine synthesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTyrosine hydroxylase is essential for synthesizing catecholamines including dopamine norepinephrine and epinephrine. This enzyme associates with other components in the catecholamine biosynthetic pathway. It functions as part of a larger complex within certain cells where its action determines levels of important neurotransmitters. These neurotransmitters help regulate numerous central and peripheral nervous system activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nTyrosine hydroxylase acts as a critical component in both the dopaminergic and adrenergic pathways. In the dopaminergic pathway tyrosine hydroxylase facilitates dopamine production influencing various physiological processes. The enzyme also correlates with ardrd protein in these pathways allowing fine-tuned control of neurotransmitter synthesis. Proteins related to tyrosine hydroxylase in these pathways include aromatic L-amino acid decarboxylase which further processes L-DOPA into dopamine.\u003cbr\u003e\nTyrosine hydroxylase has connections with neurodegenerative diseases like Parkinson's disease and conditions such as dystonia. Dysfunctional expression or activity of this enzyme can lead to dopamine deficiency contributing to the motor symptoms in Parkinson's disease. In dystonia alterations in tyrosine hydroxylase activity affect neurotransmitter balance influencing muscle coordination. The relationship with ardrd protein highlights tyrosine hydroxylase's role in maintaining neural health and it highlights potential areas for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844044705961,"sku":"ab137869","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab137869","provider":"Iright","version":"1.0","type":"link"}