{"product_id":"abcam-ab13810","title":"Abcam, ab13810, Anti-TRIF antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal TRIF antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 63 publications. Immunogen corresponding to Synthetic Peptide within Mouse Ticam1 aa 100-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Mouse Ticam1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q80UF7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRIF also known as TIR-domain-containing adapter-inducing interferon-β is an adapter protein that plays an important role in the immune response. It has a molecular mass of about 85 kDa. TRIF is expressed in various tissues but most highly in immune cells like macrophages and dendritic cells. Mechanically TRIF acts within the signaling pathways by connecting Toll-like receptors (TLR) with downstream signaling molecules. It is essential for activating pathways that lead to the production of type I interferons and other cytokines.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRIF is part of the innate immune response mechanism. It functions as a central component in signal transduction processes especially in response to pathogen-associated molecular patterns (PAMPs). TRIF often forms complexes with other signaling proteins to activate transcription factors such as IRF3 and NF-kB which stimulate the expression of inflammatory cytokines and antiviral genes. This function allows the body to respond quickly to infections and initiate immune defenses.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRIF participates in important immune signaling pathways notably the TLR and interferon signaling pathways. In the TLR pathway TRIF interacts with proteins such as MyD88 and TRAF6 to propagate signals from TLR4 critical in detecting Gram-negative bacteria. Through its role in the interferon signaling pathway TRIF helps in the regulation of antiviral responses and is essential for the expression of interferon-stimulated genes that combat viral infections.\u003cbr\u003e\nTRIF is associated with conditions involving abnormal immune responses such as autoimmune disorders and sepsis. Dysregulation of TRIF-mediated signaling can lead to excessive inflammation or defective immune responses contributing to disease pathogenesis. For example an overactive TRIF pathway may lead to increased susceptibility to sepsis due to augmented inflammatory cytokine production. TRIF also connects with proteins like IRF3 and NF-kB which are often implicated in autoimmune conditions due to their roles in persistent inflammation and immune cell activation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850109833385,"sku":"ab13810","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab13810","provider":"Iright","version":"1.0","type":"link"}