{"product_id":"abcam-ab13820","title":"Abcam, ab13820, Anti-TXNDC5 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nGoat Polyclonal TXNDC5 antibody. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human TXNDC5 aa 400 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TXNDC5 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NBS9,\u003cbr\u003e\nSpecificity:This antibody is expected to be able to recognise both reported human isoforms, as represented by NP_110437; NP_071368.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTXNDC5 also known as Thioredoxin Domain-Containing Protein 5 is an endoplasmic reticulum-resident protein with a molecular mass of approximately 48 kDa. This protein functions as a disulfide isomerase assisting in the formation and rearrangement of disulfide bonds in newly synthesized proteins. Researchers note its high expression in tissues such as the liver lung and heart where protein folding demands are significant. Due to its involvement in protein folding TXNDC5 maintains cellular homeostasis and assists in proper protein assembly.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTXNDC5 contributes to the oxidative folding of proteins within the endoplasmic reticulum. The protein does not act alone but as part of a larger complex involving other chaperones and foldases that together ensure protein quality control. TXNDC5 interfaces with the redox system impacting the oxidative environment necessary for correct protein folding. By contributing to this complex system TXNDC5 helps prevent the accumulation of misfolded proteins and maintains the integrity of cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nTXNDC5 plays a role in the protein folding pathway which is vital to maintaining cellular stability. In addition its involvement in the response to unfolded protein responses signifies its importance in stress-related pathways. TXNDC5 often interacts with other proteins such as PDI (Protein Disulfide Isomerase) and Calreticulin which are also important in protein folding and cellular stress responses. These pathways are essential for adapting to changes in protein synthesis demands and mitigating the effects of cellular stress.\u003cbr\u003e\nTXNDC5 has associations with conditions such as rheumatoid arthritis and certain cancers. Aberrant expression levels of TXNDC5 correlate with increased inflammatory responses in rheumatoid arthritis indicating its role in disease progression. In cancer overexpression of this protein has been observed suggesting a potential role in tumor growth and survival. Additionally TXNDC5 interacts with proteins like Hsp70 (Heat Shock Protein 70) which also plays a role in these disorders by assisting in protein folding under stress conditions thereby potentially influencing disease outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850101051561,"sku":"ab13820","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab13820","provider":"Iright","version":"1.0","type":"link"}