{"product_id":"abcam-ab141224","title":"Abcam, ab141224, Vancomycin hydrochloride, Tricyclic glycopeptide antibiotic","description":"\u003cp\u003eSize: 250mg \/ 1g\u003cbr\u003e\nMW 1449.2 Da, Purity \u0026gt;95%. Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1404-90-6,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:1449.2 Da,\u003cbr\u003e\nMolecular formula:C66H75Cl2N9O24,\u003cbr\u003e\nPubChem:14969,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mM,\u003cbr\u003e\nBiochemical name:Vancomycin,\u003cbr\u003e\nBiological description:Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active in vivo.,\u003cbr\u003e\nCanonical smiles:CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O,\u003cbr\u003e\nIsomeric smiles:C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O,\u003cbr\u003e\nInChi:InChI=1S\/C66H75Cl2N9O24\/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92\/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)\/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-\/m0\/s1,\u003cbr\u003e\nInChiKey:MYPYJXKWCTUITO-LYRMYLQWSA-N,\u003cbr\u003e\nIUPAC Name:(1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlbumin alpha 2a adrenergic receptor also known as ADRA2A is a G protein-coupled receptor with a mass of approximately 50 kDa. This receptor is mainly expressed in the central nervous system including the brain and in peripheral tissues like the pancreas. It binds to catecholamines such as norepinephrine playing a role in regulating various physiological functions. The presence of glycopeptide structures suggests post-translational modifications that can affect the receptor's activity and stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe alpha 2a adrenergic receptor is associated with inhibitory neurotransmitter release and can form part of a receptor complex influencing processes like vasoconstriction and insulin secretion. It also modulates the release of epinephrine and norepinephrine from the adrenal glands impacting blood pressure and stress responses. In pancreatic tissues this receptor's activity influences insulin release illustrating its role in glucose metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nAlpha 2a adrenergic receptor functions prominently in the sympathetic nervous system pathways and the regulation of neurotransmitter release. It interacts closely with other adrenergic receptors such as beta adrenergic receptors to maintain cardiovascular homeostasis. The signaling pathways it engages often involve G protein-mediated pathways that influence cyclic AMP levels affecting downstream cellular effects significant for both cardiovascular and metabolic homeostasis.\u003cbr\u003e\nThe alpha 2a adrenergic receptor has been connected to conditions such as hypertension and type 2 diabetes. In hypertension its role in vasoconstriction and neurotransmitter release affects vascular resistance and blood pressure regulation. Studies have noted its interaction with insulin and other metabolic hormones making it a receptor of interest in type 2 diabetes research. Dysregulation of this receptor is under investigation for its contributions to these conditions potentially opening pathways for targeted therapies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847491113129,"sku":"ab141224","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab141224","provider":"Iright","version":"1.0","type":"link"}