{"product_id":"abcam-ab141418","title":"Abcam, ab141418, E-64, cysteine protease inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 357.41 Da, Purity \u0026gt;99%. Irreversible, potent, and selective cysteine protease inhibitor (IC 50  values for cathepsins K, S, and L,  in vitro , are 1.4, 4.1, and 2.5 nM, respectively). Does not inhibit serine proteases (except trypsin).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:66701-25-5,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:357.41 Da,\u003cbr\u003e\nMolecular formula:C15H27N5O5,\u003cbr\u003e\nPubChem:439487,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 50 mMSoluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane,\u003cbr\u003e\nBiological description:Irreversible, potent, and selective cysteine protease inhibitor (IC50 values for cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively). Does not inhibit serine proteases (except trypsin).,\u003cbr\u003e\nCanonical smiles:CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O,\u003cbr\u003e\nIsomeric smiles:CC(C)C[C@@H](C(=O)NCCCCN=C(N)N)NC(=O)[C@H]1[C@@H](O1)C(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C15H27N5O5\/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17\/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)\/t9-,10+,11+\/m0\/s1,\u003cbr\u003e\nInChiKey:LTLYEAJONXGNFG-HBNTYKKESA-N,\u003cbr\u003e\nIUPAC Name:(2R,3R)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1739 E-64. 1739-25 is the same size as the 25 mg size of ab141418.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCathepsin B Cathepsin L and Cathepsin S are lysosomal cysteine proteases that function in the degradation of proteins. Cathepsin B also known as APP secretase has a molecular weight of about 25-30 kDa. Cathepsin L also referred to as MEP weighs approximately 24-29 kDa. Meanwhile Cathepsin S possesses a mass of around 24 kDa. These cathepsins express in various cell types including macrophages neutrophils and epithelial cells as well as in tissues such as the liver kidney and spleen. The expression of these enzymes allows for the processing and breakdown of intracellular and extracellular proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese cathepsins play key roles in protein catabolism and are significant contributors to cellular homeostasis. While not typically part of protein complexes these proteases do interact with other molecular components to achieve protein turnover in lysosomal compartments. They participate in processes like antigen presentation and the maintenance of the extracellular matrix. Their activity continues to regulate immune responses and cellular remodeling by cleaving specific peptide substrates.\u003cbr\u003e\nPathways\u003cbr\u003e\nCathepsins B L and S engage prominently in pathways such as the immune response pathway and apoptosis. During immune response they influence the degradation of antigenic proteins for presentation to the immune system. In apoptosis these proteases modulate the proteolytic cascade that breaks down cellular components linking them to proteins like caspases which are central to the cell death pathway. Their involvement in these pathways highlights their critical regulatory roles in cellular processes.\u003cbr\u003e\nDysregulation of Cathepsin B L and S relates to conditions like cancer and neurodegenerative diseases. In cancer these proteases contribute to tumor invasion and metastasis through their action on the extracellular matrix where they may interact with proteins like matrix metalloproteinases. In neurodegenerative diseases such as Alzheimer's Cathepsin B has implications due to its role in amyloid precursor protein processing. The altered activity of these cathepsins may enhance pathological proteolysis therefore linking them to the progression of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847474139305,"sku":"ab141418","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab141418","provider":"Iright","version":"1.0","type":"link"}