{"product_id":"abcam-ab141464","title":"Abcam, ab141464, PD 150606, Calpain inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 306.12 Da, Purity \u0026gt;98%. Potent, selective and cell-permeable Ca 2+ -dependent calpain inhibitor (K i  values are 210 and 370 nM for calpain-1 and calpain-2 respectively). Non-competitive and non-peptide. Irreversibly inhibits I Ca  through AMPA receptors. Anti-ischemic effects  in vivo.  .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:179528-45-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:306.12 Da,\u003cbr\u003e\nMolecular formula:C9H7IO2S,\u003cbr\u003e\nPubChem:9839500,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid,\u003cbr\u003e\nBiological description:Potent, selective and cell-permeable Ca2+-dependent calpain inhibitor (Ki values are 210 and 370 nM for calpain-1 and calpain-2 respectively). Non-competitive and non-peptide. Irreversibly inhibits ICa through AMPA receptors. Anti-ischemic effects in vivo.,\u003cbr\u003e\nCanonical smiles:C1=CC(=CC=C1C=C(C(=O)O)S)I,\u003cbr\u003e\nIsomeric smiles:C1=CC(=CC=C1\/C=C(\/C(=O)O)\\S)I,\u003cbr\u003e\nInChi:InChI=1S\/C9H7IO2S\/c10-7-3-1-6(2-4-7)5-8(13)9(11)12\/h1-5,13H,(H,11,12)\/b8-5-,\u003cbr\u003e\nInChiKey:DJCVSFWGKYHMKH-YVMONPNESA-N,\u003cbr\u003e\nIUPAC Name:(Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1906 PD 150, 606. 1906-25 is the same size as the 25 mg size of ab141464.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCalpain 2 also known as m-calpain and Calpain 1 known as u-calpain are calcium-dependent non-lysosomal cysteine proteases. They have an approximate mass of 80 kDa for the large catalytic subunit. These proteins exist ubiquitously across various tissues in mammals. Mechanically Calpain 2 and Calpain 1 modulate a multitude of cellular processes by cleaving specific substrates in a calcium-dependent manner. Both require different calcium concentrations for activation with Calpain 2 needing higher levels compared to Calpain 1.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese calpains play important roles in cytoskeletal remodeling signal transduction and cell cycle progression. They function independently and do not belong to any larger complex. Their ability to specifically cleave substrates means they finely tune cellular functions and contribute to the cell’s response to various stimuli. Misregulation of Calpain activity may lead to developmental abnormalities or disease states reflecting their importance in controlled proteolysis within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nCalpain 1 and Calpain 2 integrate into the calcium signaling and apoptosis pathways. They can modulate proteins such as the caspase precursors preventing unnecessary cell death and ensuring proper cell cycle regulation. Furthermore Calpain involvement in the Wnt signaling pathway affects cellular processes related to proliferation and differentiation. These interactions demonstrate Calpains’ connections to key cellular processes and how they influence both cell survival and development.\u003cbr\u003e\nAberrant Calpain activity is linked to muscular dystrophies and Alzheimer's disease. Overactivation of Calpain can cause excessive proteolysis contributing to muscle tissue degradation in muscular dystrophies. Similarly they may disrupt neuronal stability affecting proteins like tau in Alzheimer's disease which further relates Calpain malfunction to amyloid-beta accumulation. Therefore understanding and potentially modulating Calpain activity are key strategies in the therapeutic targeting of these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847395791017,"sku":"ab141464","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab141464","provider":"Iright","version":"1.0","type":"link"}