{"product_id":"abcam-ab141472","title":"Abcam, ab141472, AMI 1, protein arginine methyltransferase inhibitor","description":"\u003cp\u003eSize: 5mg-TRIAL \/ 25mg\u003cbr\u003e\nMW 548.5 Da, Purity 99%. Potent, selective and reversible protein arginine methyltransferase inhibitor (IC 50  = 1.63 μM). ROS° scavenger with antioxidant effects (IC 50  = 8.3 μM). Inhibits arginine  in vitro  without competing for the AdoMet binding site. Modulates nuclear receptor-regulated transcription  in vivo . Cell-permeable.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:20324-87-2,\u003cbr\u003e\nPurity:99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:548.5 Da,\u003cbr\u003e\nMolecular formula:C21H14N2Na2O9S2,\u003cbr\u003e\nPubChem:88489,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:?19.1 mg\/mL in H2OInsoluble in EtOH; insoluble in DMSO,\u003cbr\u003e\nBiochemical name:Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate),\u003cbr\u003e\nBiological description:Potent, selective and reversible protein arginine methyltransferase inhibitor (IC50 = 1.63 μM). ROS° scavenger with antioxidant effects (IC50 = 8.3 μM). Inhibits arginine in vitro without competing for the AdoMet binding site. Modulates nuclear receptor-regulated transcription in vivo. Cell-permeable.,\u003cbr\u003e\nCanonical smiles:C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)O)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+],\u003cbr\u003e\nInChi:InChI=1S\/C21H16N2O9S2.2Na\/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;\/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;\/q;2*+1\/p-2,\u003cbr\u003e\nInChiKey:MOUNHKKCIGVIDI-UHFFFAOYSA-L,\u003cbr\u003e\nIUPAC Name:disodium;4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSIRT1 also known as Silent Information Regulator T1 is a NAD+-dependent deacetylase with a mass of approximately 120 kDa. It influences numerous cellular processes through the removal of acetyl groups from target proteins. SIRT1 is primarily expressed in the nucleus with significant presence in the brain liver muscle and adipose tissue. Another target PRMT1 is a type I protein arginine methyltransferase involved in the methylation of arginine residues on proteins. PRMT1 catalyzes the transfer of methyl groups to the guanidino nitrogen of arginines playing a critical role in regulating protein function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSIRT1 impacts cellular homeostasis mediating responses to nutrient availability and stress by interacting with several transcription factors. It participates in regulating metabolism inflammation and aging processes. PRMT1 on the other hand affects gene expression and signal transduction via methylation of histones and non-histone proteins. PRMT1 operates as part of protein complexes cooperating with other methyltransferases and transcriptional regulators to control cellular growth and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nBoth SIRT1 and PRMT1 integrate into critical regulatory networks. SIRT1 plays a significant role in the SIRT1\/AMPK and SIRT1\/NF-κB pathways modulating energy metabolism and inflammatory responses. PRMT1 contributes to the Hedgehog and estrogen signaling pathways influencing gene transcription and cellular proliferation. Through these networks SIRT1 links to AMP-activated protein kinase (AMPK) which is paramount in energy balance while PRMT1 interacts with estrogen receptors affecting hormonal regulation.\u003cbr\u003e\nSIRT1 has associations with metabolic conditions such as diabetes and neurodegenerative disorders like Alzheimer’s disease. SIRT1 influences insulin sensitivity and amyloid-beta peptide clearance in these contexts. PRMT1 is implicated in cancer and cardiovascular diseases where aberrant methylation patterns disrupt normal cell cycle regulation and vascular function. In cancer PRMT1 modulates the activities of proteins like the tumor suppressor p53 affecting apoptosis and cell growth control.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847477907625,"sku":"ab141472","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab141472","provider":"Iright","version":"1.0","type":"link"}