{"product_id":"abcam-ab141492","title":"Abcam, ab141492, RO 20-1724, Phosphodiesterase 4 (PDE4) inhibitor","description":"\u003cp\u003eSize: 50mg \/ 250mg\u003cbr\u003e\nMW 278.35 Da, Purity \u0026gt;99%. Selective cAMP-specific phosphodiesterase 4 (PDE4) inhibitor (IC 50  = 3 μM). Centrally active  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:29925-17-5,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:278.35 Da,\u003cbr\u003e\nMolecular formula:C15H22N2O3,\u003cbr\u003e\nPubChem:5087,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100 mM,\u003cbr\u003e\nBiochemical name:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,\u003cbr\u003e\nBiological description:Selective cAMP-specific phosphodiesterase 4 (PDE4) inhibitor (IC50 = 3 μM). Centrally active in vivo.,\u003cbr\u003e\nCanonical smiles:CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC,\u003cbr\u003e\nInChi:InChI=1S\/C15H22N2O3\/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12\/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18),\u003cbr\u003e\nInChiKey:PDMUULPVBYQBBK-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2042 RO 20-1724. 2042-250 is the same size as the 250 mg size of ab141492.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPhosphodiesterase 4B (PDE4B) also known as PDE4B2 is an enzyme that specifically breaks down cyclic adenosine monophosphate (cAMP) to AMP an important process in cellular signaling. It belongs to the PDE4 family which is characterized by its ability to regulate the concentration of cAMP within cells. PDE4B has a molecular mass of approximately 75 kDa and is frequently expressed in immune cells including monocytes and neutrophils as well as in the brain.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDE4B plays a significant role in modulating intracellular signaling by controlling the levels of cAMP a second messenger involved in various cellular processes. As part of the larger PDE4 family complex PDE4B assists in fine-tuning immune responses and inflammatory processes. This enzyme modulates the activity of protein kinase A (PKA) impacting processes such as cell proliferation differentiation and apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDE4B operates within the cAMP signaling pathway which is essential for transducing extracellular signals into cellular responses. This pathway involves interaction with other proteins such as PKA and CREB (cAMP response element-binding protein) which are critical for regulating gene expression and cellular functions. PDE4B's ability to modulate this pathway makes it fundamental in controlling the dynamics of cellular signaling.\u003cbr\u003e\nPDE4B has been associated with inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Its involvement in regulating cAMP levels affects the inflammatory response linking it to the pathogenesis of these conditions. Additionally PDE4B influences the activity of inflammatory mediators and cytokines contributing to disease progression and symptoms. For example PDE4 inhibitors can modulate these pathways presenting potential therapeutic opportunities for managing related inflammatory disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847495176361,"sku":"ab141492","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab141492","provider":"Iright","version":"1.0","type":"link"}