{"product_id":"abcam-ab141806","title":"Abcam, ab141806, N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 437.6 Da, Purity \u0026gt;98%. Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:59880-97-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:437.6 Da,\u003cbr\u003e\nMolecular formula:C21H31N3O5S,\u003cbr\u003e\nPubChem:443295,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 5 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:N-Formyl-Met-Leu-Phe,\u003cbr\u003e\nCanonical smiles:CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O,\u003cbr\u003e\nIsomeric smiles:CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CCSC)NC=O,\u003cbr\u003e\nInChi:InChI=1S\/C21H31N3O5S\/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15\/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)\/t16-,17-,18-\/m0\/s1,\u003cbr\u003e\nInChiKey:PRQROPMIIGLWRP-BZSNNMDCSA-N,\u003cbr\u003e\nIUPAC Name:(2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions|The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFPR1 also known as formyl peptide receptor 1 is a G-protein coupled receptor with a molecular mass of approximately 38 kDa. It is also referred to as FPRL1 or RFP and recognizes bacterial n-formyl-methionyl peptides such as fMLP n-formyl-meth-leu-phe and formylated peptides. These receptors are majorly expressed in leukocytes where they contribute to host defense mechanisms.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe FPR1 receptor engages in the detection and response to bacterial infections and is not part of a larger complex. It operates by recognizing n-formyl peptides released by bacteria and mitochondria during cell stress facilitating chemical signaling for immune responses. This receptor helps mediate chemotaxis where immune cells like neutrophils are directed towards sites of infection or tissue damage promoting an effective immune response.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe FPR1 receptor is significantly involved in the chemokine signaling pathway where it guides the migration of leucocytes and the innate immune response pathway initiating rapid responses to foreign invaders. It interacts closely with proteins such as G-proteins which transduce signals internally after activation by n-formyl peptides to achieve adequate movement and function of immune components.\u003cbr\u003e\nFPR1 has associations with chronic inflammatory conditions and infection-related disorders. For instance its dysregulation can contribute to diseases like chronic obstructive pulmonary disease (COPD) and certain autoimmune disorders. This receptor's role in inflammation and host defense connects it with proteins such as other receptors that participate in immune regulation collectively impacting disease progression and severity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847446843561,"sku":"ab141806","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab141806","provider":"Iright","version":"1.0","type":"link"}