{"product_id":"abcam-ab142052","title":"Abcam, ab142052, Gefitinib, EGFR tyrosine kinase inhibitor","description":"\u003cp\u003eSize: 50mg \/ 250mg\u003cbr\u003e\nMW 446.9 Da, Purity \u0026gt;98%. Orally active, potent, selective EGFR (Epidermal growth factor receptor) tyrosine kinase inhibitor (IC 50  = 33 nM). Inhibits EGF-stimulated EGFR autophosphorylation and inhibits tumor growth  in vivo . Enhances efficacy of cytotoxic agents. Inhibits growth factor production and angiogenesis. Clinically useful anticancer agent.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:184475-35-2,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:446.9 Da,\u003cbr\u003e\nMolecular formula:C22H24ClFN4O3,\u003cbr\u003e\nPubChem:123631,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:Gefitinib,\u003cbr\u003e\nBiological description:Orally active, potent, selective EGFR (Epidermal growth factor receptor) tyrosine kinase inhibitor (IC50 = 33 nM). Inhibits EGF-stimulated EGFR autophosphorylation and inhibits tumor growth in vivo. Enhances efficacy of cytotoxic agents. Inhibits growth factor production and angiogenesis. Clinically useful anticancer agent.,\u003cbr\u003e\nCanonical smiles:COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4,\u003cbr\u003e\nInChi:InChI=1S\/C22H24ClFN4O3\/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15\/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27),\u003cbr\u003e\nInChiKey:XGALLCVXEZPNRQ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847396118697,"sku":"ab142052","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab142052","provider":"Iright","version":"1.0","type":"link"}