{"product_id":"abcam-ab142160","title":"Abcam, ab142160, SAG (Smo agonist), Smoothened agonist","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 490.1 Da, Purity \u0026gt;98%. Cell-permeable, selective, potent Smoothened agonist (EC 50  = 3 nM). Binds the Smo heptahelical bundle that antagonizes cyclopamine (ab120392) action. Active  in vitro  and  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:364590-63-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:490.1 Da,\u003cbr\u003e\nMolecular formula:C28H28ClN3OS,\u003cbr\u003e\nPubChem:5284330,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:Smoothened agonist,\u003cbr\u003e\nBiological description:Cell-permeable, selective, potent Smoothened agonist (EC50 = 3 nM). Binds the Smo heptahelical bundle that antagonizes cyclopamine (ab120392) action. Active in vitro and in vivo.,\u003cbr\u003e\nCanonical smiles:CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C28H28ClN3OS\/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20\/h2-8,13-17,22-23,30H,9-12,18H2,1H3,\u003cbr\u003e\nInChiKey:VFSUUTYAEQOIMW-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSmoothened (SMO) is a protein that plays a vital role in the Hedgehog signaling pathway. It is also known by other names such as SMOH and Smoothened homolog. This protein has a molecular mass of approximately 86 kDa. Smoothened is expressed in a variety of tissues including the brain lungs and kidneys. It functions as a transmembrane protein with seven helices which transmits signals across the cell membrane.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSmoothened influences cellular processes by participating in the Hedgehog signaling pathway. It operates as part of a complex with the Patched (PTCH) receptor. When the Hedgehog ligand binds to PTCH Smoothened becomes activated. This activation leads to changes in gene expression that control cell growth and differentiation. Smoothened is critical in embryonic development tissue regeneration and stem cell maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nSmoothened interacts with essential components of the Hedgehog signaling pathway. This pathway includes proteins like PTCH and Gli transcription factors. Smoothened activation triggers the release of these Gli proteins from inhibitory complexes which then migrate to the nucleus to modulate the transcription of target genes. The Hedgehog pathway is important in regulating developmental processes and cellular responses.\u003cbr\u003e\nSmoothened has connections to various forms of cancer including basal cell carcinoma and medulloblastoma. Abnormal activation or mutations in Smoothened can lead to unchecked cell proliferation. Smoothened also shows relevance in the development of gliomas. Drugs like 'anti smo' or 'glasdegib' act as Smoothened antagonists aiming to inhibit its function in these diseases by targeting the Hedgehog signaling pathway.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847408472233,"sku":"ab142160","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab142160","provider":"Iright","version":"1.0","type":"link"}