{"product_id":"abcam-ab142177","title":"Abcam, ab142177, ML130, NOD1 inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 287.34 Da, Purity \u0026gt;97%. Potent, selective NOD1 inhibitor (IC 50  = 560 nM). Inhibits NOD1-induced NF-κB activation  in vitro . Cell-permeable.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:799264-47-4,\u003cbr\u003e\nPurity:\u0026gt;97%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:287.34 Da,\u003cbr\u003e\nMolecular formula:C14H13N3O2S,\u003cbr\u003e\nPubChem:1088438,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 10 mM,\u003cbr\u003e\nBiochemical name:Nodinitib-1,\u003cbr\u003e\nBiological description:Potent, selective NOD1 inhibitor (IC50 = 560 nM). Inhibits NOD1-induced NF-κB activation in vitro. Cell-permeable.,\u003cbr\u003e\nCanonical smiles:CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N,\u003cbr\u003e\nInChi:InChI=1S\/C14H13N3O2S\/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15\/h2-9H,1H3,(H2,15,16),\u003cbr\u003e\nInChiKey:SRFABRWQVPCPRG-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-(4-methylphenyl)sulfonylbenzimidazol-2-amine\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1974 ML130. 1974-25 is the same size as the 25 mg size of ab142177.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInterleukin-8 (IL-8) also known as CXCL8 is a chemokine with a mass of approximately 8 kDa. It plays a role in the immune response by attracting neutrophils to sites of inflammation. IL-8 is expressed in various cells including macrophages epithelial cells and airway smooth muscle cells. Another related target is NOD1 (nucleotide-binding oligomerization domain-containing protein 1) which senses bacterial peptidoglycans and helps trigger immune reactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis family of proteins functions in the immune system to mediate inflammatory responses. IL-8 initiates the movement and activation of neutrophils while NOD1 acts as an intracellular pattern recognition receptor. Together they form part of a complex network that protects the body from infections by activating immune cells and promoting the production of cytokines.\u003cbr\u003e\nPathways\u003cbr\u003e\nIL-8 and NOD1 participate in important signaling pathways that regulate immune response and inflammation. IL-8 is involved in the chemokine signaling pathway influencing other proteins like CXCR1 and CXCR2 receptors on leukocytes. NOD1 participates in the NF-κB pathway which involves proteins like RIP2 kinase playing a role in inflammatory signal transduction.\u003cbr\u003e\nIL-8 and NOD1 have significant implications in various immune-related conditions. For IL-8 its overexpression often relates to chronic inflammatory diseases like rheumatoid arthritis. NOD1 is associated with inflammatory bowel disease where its activity contributes to intestinal inflammation. In these contexts IL-8 works alongside CXCR receptors while NOD1 interacts with RIP2 kinase to influence disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847430623401,"sku":"ab142177","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab142177","provider":"Iright","version":"1.0","type":"link"}