{"product_id":"abcam-ab143594","title":"Abcam, ab143594, Cholecalciferol (Vitamin D3), VDR activator","description":"\u003cp\u003eSize: 5g\u003cbr\u003e\nMW 384.6 Da, Purity \u0026gt;98%. VDR activator. Induces cell differentiation and shows antiproliferative effects. Metabolic calcifediol (ab142766) precursor. Shows antioxidant and anti-inflammatory effects  in vivo.  Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:67-97-0,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:384.6 Da,\u003cbr\u003e\nMolecular formula:C27H44O,\u003cbr\u003e\nPubChem:5280795,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanolSoluble in DMSO,\u003cbr\u003e\nBiochemical name:Cholecalciferol,\u003cbr\u003e\nBiological description:VDR activator. Induces cell differentiation and shows antiproliferative effects. Metabolic calcifediol (ab142766) precursor. Shows antioxidant and anti-inflammatory effects in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C,\u003cbr\u003e\nIsomeric smiles:C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC\/C2=C\\C=C\/3\\C[C@H](CCC3=C)O)C,\u003cbr\u003e\nInChi:InChI=1S\/C27H44O\/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3\/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3\/b22-12+,23-13-\/t21-,24+,25-,26+,27-\/m1\/s1,\u003cbr\u003e\nInChiKey:QYSXJUFSXHHAJI-YRZJJWOYSA-N,\u003cbr\u003e\nIUPAC Name:(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe alpha 1 Glycine Receptor (GLRA1) and Vitamin D Receptor (VDR) have distinct roles yet some interconnected pathways. GLRA1 often known as the glycine receptor is a ligand-gated ion channel found in the central nervous system. This receptor with a mass of approximately 48 kDa facilitates fast synaptic transmission by allowing chloride ions to pass through the cell membrane leading to inhibitory neurotransmission. In contrast the Vitamin D Receptor primarily a nuclear receptor belongs to the NR1I1 family and functions in regulating gene expression. The VDR is expressed in various tissues including intestine bone brain and immune cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe alpha 1 Glycine Receptor contributes to the control of motor and sensory processing. It forms part of a pentameric complex in conjunction with other glycine receptor subunits to exert its inhibitory effect on neuronal transmission. The Vitamin D Receptor on the other hand plays a regulatory role in calcium and phosphate homeostasis and bone mineralization. This receptor mediates the effects of 125-dihydroxyvitamin D3 the active form of vitamin D by binding it and facilitating its action on gene transcription for various biological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral actions of the alpha 1 Glycine Receptor impact the inhibition pathway related to neuronal signaling involving proteins such as gephyrin which stabilizes receptor clustering. The Vitamin D Receptor is important in the calcium signaling pathway and works closely with parathyroid hormone. These pathways further integrate into broader regulatory mechanisms affecting homeostasis and cellular response.\u003cbr\u003e\nMutations in the GLRA1 gene can lead to neurological conditions like hyperekplexia also known as startle disease where its improper function alters inhibitory control. The Vitamin D Receptor links to disorders like osteoporosis due to its role in bone density regulation; its interaction with other nuclear receptors such as the retinoid X receptor affects bone homeostasis. Understanding these targets helps in unraveling the complexities of neuronal and metabolic disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847484985513,"sku":"ab143594","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab143594","provider":"Iright","version":"1.0","type":"link"}