{"product_id":"abcam-ab143833","title":"Abcam, ab143833, LY 2228820, p38 MAPK inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 612.7 Da, Purity \u0026gt;98%. LY 2228820 is a novel and potent p38 MAPK inhibitor with potent anti-inflammatory activity. It significantly inhibited phosphorylation of MAPKAPK2 and\/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY 2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events. IC 50  of 7 nM in a cell-free assay.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:862507-23-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:612.7 Da,\u003cbr\u003e\nMolecular formula:C26H37FN6O6S2,\u003cbr\u003e\nPubChem:11570805,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 163.2 mMSoluble in DMSO to 6.52 mMSoluble in Ethanol to 4.89 mM,\u003cbr\u003e\nBiochemical name:Ralimetinib Mesylate,\u003cbr\u003e\nBiological description:LY 2228820 is a novel and potent p38 MAPK inhibitor with potent anti-inflammatory activity. It significantly inhibited phosphorylation of MAPKAPK2 and\/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY 2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events. IC50 of 7 nM in a cell-free assay.,\u003cbr\u003e\nCanonical smiles:CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C24H29FN6.2CH4O3S\/c1-23(2,3)13-31-20-17(28-22(31)26)12-11-16(27-20)19-18(14-7-9-15(25)10-8-14)29-21(30-19)24(4,5)6;2*1-5(2,3)4\/h7-12H,13H2,1-6H3,(H2,26,28)(H,29,30);2*1H3,(H,2,3,4),\u003cbr\u003e\nInChiKey:NARMJPIBAXVUIE-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine;methanesulfonic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1702 LY2228820. B1702-25 is the same size as the 25 mg size of ab143833.\u003cbr\u003e\nProtect from air and light.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847454740649,"sku":"ab143833","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab143833","provider":"Iright","version":"1.0","type":"link"}