{"product_id":"abcam-ab144540","title":"Abcam, ab144540, U-46619, Thromboxane A2 receptor agonist","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 350.5 Da, Purity \u0026gt;98%. Potent thromboxane A2 agonist (EC50 = 35 nM). Activates p38, ERK-1 and ERK-2. Induces platelet aggregation and shows vasoconstrictive effects *in vivo.*.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:56985-40-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nMolecular weight:350.5 Da,\u003cbr\u003e\nMolecular formula:C21H34O4,\u003cbr\u003e\nPubChem:5311493,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:9,11-Methanoepoxy PGH2,\u003cbr\u003e\nBiological description:Potent thromboxane A2 agonist (EC50 = 35 nM). Activates p38, ERK-1 and ERK-2. Induces platelet aggregation and shows vasoconstrictive effects *in vivo.*,\u003cbr\u003e\nCanonical smiles:CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)CO2)O,\u003cbr\u003e\nIsomeric smiles:CCCCC[C@@H](\/C=C\/[C@H]1[C@H]2C[C@@H]([C@@H]1C\/C=C\\CCCC(=O)O)CO2)O,\u003cbr\u003e\nInChi:InChI=1S\/C21H34O4\/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24\/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)\/b7-4-,13-12+\/t16-,17+,18+,19-,20-\/m1\/s1,\u003cbr\u003e\nInChiKey:LQANGKSBLPMBTJ-BRSNVKEHSA-N,\u003cbr\u003e\nIUPAC Name:(Z)-7-[(1R,4S,5S,6R)-6-[(E,3S)-3-hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab144540 is soluble in DMF (100mg\/ml), DMSO, 100% ethanol, DMSO, or PBS, pH 7.2 (2mg\/ml).\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Thromboxane A2 receptor (TBXA2R) also known as the thromboxane prostanoid receptor is a G protein-coupled receptor with a molecular mass of approximately 70 kDa. This receptor is important for mediating the effects of thromboxane A2 a lipid-derived molecule involved in vasoconstriction and platelet aggregation. TBXA2R expresses predominantly in platelets smooth muscle cells and in some types of leukocytes. The receptor's activity is mediated through Gq proteins causing changes in intracellular calcium levels which trigger various cellular responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWithin the context of cellular signaling TBXA2R plays vital roles in hemostasis and thrombosis through its impact on platelet activation and vascular tone regulation. When thromboxane A2 binds to TBXA2R the receptor undergoes conformational changes activating intracellular signaling cascades that facilitate these physiological processes. TBXA2R operates as part of a signaling complex that includes other receptors and regulatory proteins modulating hemostatic balance and vascular reactivity.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis receptor fits centrally into the arachidonic acid pathway influencing hemostatic and inflammatory responses. It closely interacts with cyclooxygenase enzymes particularly COX-1 involved in thromboxane A2 synthesis. TBXA2R also integrates into the prostaglandin synthesis pathway interacting with related prostanoid receptors sharing similar signaling mechanisms but differing physiological outcomes. These pathways reveal TBXA2R's significance as a cytoplasmic marker for activity related to vascular homeostasis.\u003cbr\u003e\nTBXA2R exhibits key associations with cardiovascular diseases including atherosclerosis and myocardial infarction. The receptor’s role in promoting platelet aggregation makes it an interesting target in these pathologies where abnormal clotting adds to disease progression. Additionally TBXA2R connects with other proteins like integrins and inhibitors of cyclooxygenase representing therapeutic targets to modulate its activity and prevent thrombotic events and inflammatory responses associated with these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847427313833,"sku":"ab144540","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab144540","provider":"Iright","version":"1.0","type":"link"}