{"product_id":"abcam-ab144641","title":"Abcam, ab144641, PR 619, DUB inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 223.3 Da, Purity \u0026gt;99%. Cell-permeable, non-selective and reversible DUB inhibitor (IC 50  values are 5 to 20 μM). Induces polyubiquitinated protein accumulation in cells without directly affecting proteasome activity. Activates autophagy.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:2645-32-1,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:223.3 Da,\u003cbr\u003e\nMolecular formula:C7H5N5S2,\u003cbr\u003e\nPubChem:2817763,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:3,5-Dithiocyanatopyridine-2,6-diamine,\u003cbr\u003e\nBiological description:Cell-permeable, non-selective and reversible DUB inhibitor (IC50 values are 5 to 20 μM). Induces polyubiquitinated protein accumulation in cells without directly affecting proteasome activity. Activates autophagy.,\u003cbr\u003e\nCanonical smiles:C1=C(C(=NC(=C1SC#N)N)N)SC#N,\u003cbr\u003e\nInChi:InChI=1S\/C7H5N5S2\/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10\/h1H,(H4,10,11,12),\u003cbr\u003e\nInChiKey:ZXOBLNBVNROVLC-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:(2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGirdin also known as GIV or Girders of actin filaments plays a significant role in cell signaling. It is a multifunctional adaptor protein with a mass of approximately 220 kDa. GIV is expressed in various tissues including the brain heart and immune cells. It acts as an important player in the reorganization of the actin cytoskeleton which is critical for cellular processes like migration and adhesion.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGIV is important for modulating signal transduction pathways. It interacts with G-protein coupled receptors (GPCRs) and growth factor receptors facilitating the activation of G-protein signaling. GIV does not typically function alone; it integrates into larger signaling complexes interfacing with other proteins to propagate signals downstream. Through these interactions it influences processes like cell proliferation and survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nGIV significantly impacts the PI3K-Akt and MAPK pathways. It acts as an upstream regulator controlling the activation of signaling cascades that determine cell fate decisions. GIV works closely with proteins such as Akt a central protein in the PI3K pathway and Grb2 linking receptor tyrosine kinases to downstream signaling mechanisms. These interactions highlight GIV’s importance in mediating cellular responses to external stimuli.\u003cbr\u003e\nGIV’s dysregulation links to cancer and metabolic disorders. In cancer GIV overexpression correlates with enhanced tumor progression and poor patient prognosis. GIV interacts with epidermal growth factor receptor (EGFR) to drive oncogenic signaling promoting tumor survival and growth. In metabolic disorders like diabetes alterations in GIV’s signaling pathways contribute to insulin resistance. Investigations into these interactions highlight the potential for targeting GIV therapeutically using inhibitors like DUB inhibitors and PR-619.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847416041641,"sku":"ab144641","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab144641","provider":"Iright","version":"1.0","type":"link"}