{"product_id":"abcam-ab145145","title":"Abcam, ab145145, Ceefourin™ 2, MRP4 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 355.7 Da, Purity \u0026gt;98%. Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:348148-51-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:355.7 Da,\u003cbr\u003e\nMolecular formula:C15H9ClF3N3O2,\u003cbr\u003e\nPubChem:1366977,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid,\u003cbr\u003e\nBiological description:Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).,\u003cbr\u003e\nCanonical smiles:CC1=CC=C(C=C1)C2=NC3=C(C(=NN3C(=C2)C(F)(F)F)C(=O)O)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C15H9ClF3N3O2\/c1-7-2-4-8(5-3-7)9-6-10(15(17,18)19)22-13(20-9)11(16)12(21-22)14(23)24\/h2-6H,1H3,(H,23,24),\u003cbr\u003e\nInChiKey:ZGYIZPUVZOKRHH-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847466733737,"sku":"ab145145","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab145145","provider":"Iright","version":"1.0","type":"link"}