{"product_id":"abcam-ab145582","title":"Abcam, ab145582, Atropine, mAChR antagonist","description":"\u003cp\u003eSize: 1g\u003cbr\u003e\nMW 289.4 Da, Purity \u0026gt;98%. Potent, competitive, non-selective mAChR antagonist (IC 50  = 2.5 nM). Induces mydriasis. Shows antimuscarinic and anticholinergic effects  in vivo . Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:51-55-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nSource:Solanaceae sp.,\u003cbr\u003e\nMolecular weight:289.4 Da,\u003cbr\u003e\nMolecular formula:C17H23NO3,\u003cbr\u003e\nPubChem:3661,\u003cbr\u003e\nNature:Native,\u003cbr\u003e\nSolubility:Soluble in water to 5 mM,\u003cbr\u003e\nBiochemical name:L-Hyoscyamine,\u003cbr\u003e\nBiological description:Potent, competitive, non-selective mAChR antagonist (IC50 = 2.5 nM). Induces mydriasis. Shows antimuscarinic and anticholinergic effects in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3,\u003cbr\u003e\nInChi:InChI=1S\/C17H23NO3\/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12\/h2-6,13-16,19H,7-11H2,1H3,\u003cbr\u003e\nInChiKey:RKUNBYITZUJHSG-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMuscarinic Acetylcholine Receptor M3 also known as CHRM3 or M3 receptor plays an important role in various physiological processes. This receptor is part of the G-protein coupled receptor family and binds acetylcholine. The mass of CHRM3 is around 65 kDa. CHRM3 is widely expressed in various tissues including smooth muscle exocrine glands and in some cases the central nervous system. This extensive expression indicates its significance in multiple bodily functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCHRM3 mediates cellular responses such as smooth muscle contraction and glandular secretion. It operates as part of a larger receptor complex that facilitates the signal transduction process. When acetylcholine binds to CHRM3 it activates downstream signaling pathways involving various intracellular messengers. This activation influences activities such as bronchoconstriction and salivation emphasizing the importance of M3 receptor in autonomic nervous system regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies show that CHRM3 engages with the inositol phospholipid-calcium signaling pathway. This pathway mobilizes calcium from intracellular stores working together with proteins like G-proteins and protein kinase C. These interactions lead to physiological effects such as muscle contraction and secretion. Moreover CHRM3 links with the MAPK\/ERK pathway conveying signals that influence cell growth and differentiation. The intertwining of these pathways highlights CHRM3’s role in regulating key cellular functions.\u003cbr\u003e\nCHRM3’s malfunction associates with asthma and chronic obstructive pulmonary disease (COPD). Dysregulated CHRM3 signaling can exacerbate symptoms involving bronchoconstriction and mucus secretion. Furthermore CHRM3 connects to proteins affecting airway smooth muscle cells intensifying disease conditions. Its relevance in exocrine gland regulation also implicates CHRM3 in conditions like Sjögren's syndrome where it may impact salivary and lacrimal gland secretion. Understanding these connections aids in developing targeted therapies for these ailments.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847421808809,"sku":"ab145582","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab145582","provider":"Iright","version":"1.0","type":"link"}