{"product_id":"abcam-ab145954","title":"Abcam, ab145954, NF-kappaB Activation Inhibitor VI, benzoxathiole compound","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 273.4 Da, Purity \u0026gt;95%. Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser 177  and\/or Ser 181  residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation (IC 50  = 1.0 μM) and nitrite production (IC 50  = 0.7 μM) in RAW 264.7 cells  in vitro  and effectively prevent LPS-induced septic death in mice  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:113760-29-5,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:273.4 Da,\u003cbr\u003e\nMolecular formula:C15H15NO2S,\u003cbr\u003e\nPubChem:13925917,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSOSoluble in ethanol,\u003cbr\u003e\nBiochemical name:1,3-Benzoxathiol-4(5H)-one, 6,7-dihydro-6,6-dimethyl-2-(phenylimino)-,\u003cbr\u003e\nBiological description:Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and\/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation (IC50 = 1.0 μM) and nitrite production (IC50 = 0.7 μM) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice in vivo.,\u003cbr\u003e\nCanonical smiles:CC1(CC2=C(C(=O)C1)SC(=NC3=CC=CC=C3)O2)C,\u003cbr\u003e\nInChi:InChI=1S\/C15H15NO2S\/c1-15(2)8-11(17)13-12(9-15)18-14(19-13)16-10-6-4-3-5-7-10\/h3-7H,8-9H2,1-2H3,\u003cbr\u003e\nInChiKey:XFSSJIQCIPSBHJ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847417221289,"sku":"ab145954","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab145954","provider":"Iright","version":"1.0","type":"link"}