{"product_id":"abcam-ab146146","title":"Abcam, ab146146, 20(S)-Hydroxycholesterol, Smoothened activator","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 402.65 g\/mol. Allosteric activator of the Hedgehog (Hh) signaling pathway Smoothened (Smo) oncoprotein. Binds at a site distinct from the canonical cyclopamine binding site. Activates Hh signaling (EC 50  = ~ 3 μM for induction of Hh reporter gene transcription in NIH 3T3 cells). Also exhibits osteogenic activity and activates the liver X receptor (LXR).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:516-72-3,\u003cbr\u003e\nMolecular weight:402.65 g\/mol,\u003cbr\u003e\nMolecular formula:C27H46O2,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiological description:Allosteric activator of the Hedgehog (Hh) signaling pathway Smoothened (Smo) oncoprotein. Binds at a site distinct from the canonical cyclopamine binding site. Activates Hh signaling (EC50 = ~ 3 μM for induction of Hh reporter gene transcription in NIH 3T3 cells). Also exhibits osteogenic activity and activates the liver X receptor (LXR).,\u003cbr\u003e\nIsomeric smiles:CC(C)CCC[C@@](C)(O)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]2[C@H]3CC=C1C[C@@H](O)CC[C@@]12C,\u003cbr\u003e\nInChi:InChI=1S\/C27H46O2\/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4\/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3\/t20-,21-,22-,23-,24-,25-,26-,27+\/m0\/s1,\u003cbr\u003e\nInChiKey:MCKLJFJEQRYRQT-MGNSQDQZSA-N\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847472238761,"sku":"ab146146","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab146146","provider":"Iright","version":"1.0","type":"link"}