{"product_id":"abcam-ab146300","title":"Abcam, ab146300, L 701324, glycine site NMDA receptor antagonist","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 363.8 Da, Purity \u0026gt;99%. Potent, selective glycine site NMDA receptor antagonist. Shows a reduced propensity to activate mesolimbic dopaminergic systems compared to MK 801 (ab120027). Shows long-acting anticonvulsant effects in  vivo.  Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:142326-59-8,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:363.8 Da,\u003cbr\u003e\nMolecular formula:C21H14ClNO3,\u003cbr\u003e\nPubChem:54682505,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-,\u003cbr\u003e\nBiological description:Potent, selective glycine site NMDA receptor antagonist. Shows a reduced propensity to activate mesolimbic dopaminergic systems compared to MK 801 (ab120027). Shows long-acting anticonvulsant effects in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:C1=CC=C(C=C1)OC2=CC=CC(=C2)C3=C(C4=C(C=C(C=C4)Cl)NC3=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C21H14ClNO3\/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15\/h1-12H,(H2,23,24,25),\u003cbr\u003e\nInChiKey:FLVRDMUHUXVRET-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe NMDA receptors which include subunits such as NMDAR2A NMDAR2B GluN2C NMDAR1 and others like NMDAR3A and 3B play a mechanical role in synaptic transmission and plasticity. These receptors known also as N-methyl-D-aspartate receptors exist predominantly in the central nervous system. They integrate into a calcium-permeable ion channel complex. NMDA receptors weigh approximately in the range of 140-180 kDa and they localize mainly within the postsynaptic membrane of neurons. Each subunit like NMDAR2A and 2B can impact the receptor's functional properties such as its ion permeability and modulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNMDA receptors serve as critical components for excitatory neurotransmission in the brain. As part of a larger receptor complex they allow for calcium entry upon activation by glutamate and co-agonists like glycine. This action triggers downstream signaling pathways that influence synaptic plasticity essential for processes like learning and memory. The interaction between different subunits provides specificity in receptor assembly and function enabling varying receptor responses to synaptic events. For instance subunit composition can determine the receptor's open probability and response to antagonists.\u003cbr\u003e\nPathways\u003cbr\u003e\nNMDA receptors integrate into the central signaling pathways of neuronal communication and plasticity particularly in processes like long-term potentiation (LTP). The receptor's activation leads to the opening of calcium channels allowing calcium influx into the neurons which then engages signaling proteins such as CaMKII and calcineurin. These signaling pathways orchestrate changes that strengthen or modify synaptic connections. The NMDA receptor activity complements the functions of other neurotransmitter systems like the AMPA receptor pathway highlighting the receptor's involvement in synaptic plasticity and overall brain function.\u003cbr\u003e\nMalfunctioning or altered NMDA receptor activity associates with neurological conditions like Alzheimer's disease and schizophrenia. Aberrations in the receptor function can lead to disrupted synaptic transmission contributing to cognitive deficits observed in Alzheimer's. In schizophrenia NMDA receptor hypofunction is linked to symptoms like psychosis and cognitive impairment. Proteins like CYP2D6 can interact with medications targeting NMDA receptors influencing treatment efficacy and side effects in these disorders. Understanding NMDA receptor function assists in exploring therapeutic strategies to tackle these complex neurological diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847456706729,"sku":"ab146300","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab146300","provider":"Iright","version":"1.0","type":"link"}