{"product_id":"abcam-ab146413","title":"Abcam, ab146413, CFM 2, AMPA receptor antagonist","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 311.33 Da, Purity \u0026gt;98%. Selective, non-competitive AMPA receptor antagonist. ERK1\/2 pathway inhibitor. Reduces CREB phosphorylation and shows antiproliferative effects. Shows potent, long-acting anticonvulsant effects  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:178616-26-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:311.33 Da,\u003cbr\u003e\nMolecular formula:C17H17N3O3,\u003cbr\u003e\nPubChem:4377504,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:1-(4-Aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one,\u003cbr\u003e\nBiological description:Selective, non-competitive AMPA receptor antagonist. ERK1\/2 pathway inhibitor. Reduces CREB phosphorylation and shows antiproliferative effects. Shows potent, long-acting anticonvulsant effects in vivo.,\u003cbr\u003e\nCanonical smiles:COC1=C(C=C2C(=C1)CC(=O)NN=C2C3=CC=C(C=C3)N)OC,\u003cbr\u003e\nInChi:InChI=1S\/C17H17N3O3\/c1-22-14-7-11-8-16(21)19-20-17(13(11)9-15(14)23-2)10-3-5-12(18)6-4-10\/h3-7,9H,8,18H2,1-2H3,(H,19,21),\u003cbr\u003e\nInChiKey:MJKADKZSYQWGLL-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-(4-aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytochrome P450 3A4 commonly known as CYP3A4 is an enzyme with a molecular mass of about 57 kDa. It plays an important role in the metabolism of drugs in the human liver and intestine. Its expression is highest in hepatic and intestinal tissues where it catalyzes the oxidation of small organic molecules. Besides CYP3A4 modifies the chemical structure of drugs and toxins affecting their activity and clearance from the body which is important for drug interaction studies. This modification can significantly impact pharmacokinetics and pharmacodynamics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCYP3A4 functions as part of the cytochrome P450 monooxygenase complex which helps with hormone synthesis and metabolism as well as the breakdown of various xenobiotics. It acts in cooperation with NADPH-cytochrome P450 reductase enabling electron transfer necessary for enzymatic reactions. Furthermore the enzyme shows a high degree of overlapping substrate specificity allowing it to metabolize a number of structurally diverse compounds including endogenous and exogenous substances. This flexibility highlights its essential role in hepatic detoxification processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nCYP3A4 is integral to the drug metabolism pathway and the steroid biosynthesis pathway. It interacts with other cytochrome P450 enzymes and transport proteins such as CYP3A5 contributing to the biotransformation of drugs and natural compounds. Its function in these pathways influences the regulation of compound levels in the body impacting drug efficacy and safety. CYP3A4 activity can alter cholesterol homeostasis and the production of biochemically active steroid hormones affecting numerous physiological processes.\u003cbr\u003e\nCYP3A4 is linked to drug-induced liver injury and cancer. Aberrant expression or mutations can lead to improper drug metabolism causing toxic accumulation and adverse drug reactions. The enzyme is often involved in the metabolic activation of procarcinogens correlating its activity with cancer risk. Additionally its interaction with P-glycoprotein influences the absorption and elimination of chemotherapeutic agents affecting treatment efficacy and patient outcomes. Understanding variations in CYP3A4 activity can aid in personalized medicine approaches to mitigate these risks.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847500386473,"sku":"ab146413","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab146413","provider":"Iright","version":"1.0","type":"link"}