{"product_id":"abcam-ab146593","title":"Abcam, ab146593, LY 294002 (DMSO solution), PI3-kinase inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 307.3 Da, Purity \u0026gt;99%. A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50  = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC 50  \u0026gt; 50 μM).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:154447-36-6,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nMolecular weight:307.3 Da,\u003cbr\u003e\nMolecular formula:C19H17NO3,\u003cbr\u003e\nPubChem:3973,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one,\u003cbr\u003e\nBiological description:A highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC50 \u0026gt; 50 μM).,\u003cbr\u003e\nCanonical smiles:C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4,\u003cbr\u003e\nInChi:InChI=1S\/C19H17NO3\/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14\/h1-8,13H,9-12H2,\u003cbr\u003e\nInChiKey:CZQHHVNHHHRRDU-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-morpholin-4-yl-8-phenylchromen-4-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDNA-PKcs (DNA-dependent protein kinase catalytic subunit) mTOR (mechanistic target of rapamycin) PLK1 (Polo-like kinase 1) PI3 Kinase p110 beta PI3 Kinase p110 delta PI3 Kinase p85 alpha GSK3 beta (Glycogen synthase kinase 3 beta) Casein Kinase 2 alpha PLK3 (Polo-like kinase 3) PI3 Kinase catalytic subunit alpha (PIK3CA) CBX1\/HP1 beta (Heterochromatin protein 1 beta) CSNK2A2 (Casein kinase 2 alpha' polypeptide) Casein Kinase 2 beta 5-HT-2B PIM1 (Proto-oncogene serine\/threonine-protein kinase) 5HT2A Receptor 5-HT2C Receptor and PIM3 are involved in various cellular processes. DNA-PKcs weighs approximately 470 kDa and is expressed in the nucleus of most cells. mTOR is a large serine\/threonine kinase central to cellular growth and is part of the mTOR complex expressed ubiquitously. These proteins exhibit varied expression across different tissues underlining their diverse roles in cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins play essential roles in cell cycle regulation survival proliferation and metabolism. DNA-PKcs as part of the DNA repair machinery collaborates within the non-homologous end joining process important for DNA repair. mTOR integrates signals from nutrients and growth factors to regulate translation. GSK3 beta is involved in glycogen metabolism. These proteins often function as parts of larger complexes such as PI3K being part of a lipid kinase complex and mTOR being in mTORC1 and mTORC2 complexes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese proteins participate in significant signaling pathways. The PI3K\/AKT\/mTOR pathway involves PI3 Kinase p110 and mTOR. This pathway is necessary for cellular growth and metabolism. DNA-PKcs integrates with DNA repair pathways. The Wnt\/beta-catenin signaling pathway involves GSK3 beta and it regulates cellular proliferation and differentiation. Interactions between these pathways highlight coordination of cellular responses to stimuli and stress.\u003cbr\u003e\nThese proteins highlight their significance in cancers and metabolic diseases. mTOR dysregulation links to cancers due to its role in cell growth and proliferation and inhibitors are used in cancer therapy. Aberrant PI3K signaling associates with insulin resistance and diabetes where the PI3 Kinase family proteins like p110 beta and p110 delta are involved. In cancer mTOR is connected with DNA-PKcs through pathways adjusting to stress and DNA damage underpinning therapeutic strategies in targeting these proteins.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847418204329,"sku":"ab146593","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab146593","provider":"Iright","version":"1.0","type":"link"}