{"product_id":"abcam-ab146679","title":"Abcam, ab146679, (R,S)-AMPA (mM\/ml), AMPA agonist","description":"\u003cp\u003eSize: 10mM \/ mL\u003cbr\u003e\nMW 186.17 Da, Purity \u0026gt;99%. Prototypic agonist for AMPA receptors. Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:77521-29-0,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:186.17 Da,\u003cbr\u003e\nMolecular formula:C7H10N2O4,\u003cbr\u003e\nPubChem:1221,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID,\u003cbr\u003e\nBiological description:Prototypic agonist for AMPA receptors.,\u003cbr\u003e\nCanonical smiles:CC1=C(C(=O)NO1)CC(C(=O)O)N,\u003cbr\u003e\nInChi:InChI=1S\/C7H10N2O4\/c1-3-4(6(10)9-13-3)2-5(8)7(11)12\/h5H,2,8H2,1H3,(H,9,10)(H,11,12),\u003cbr\u003e\nInChiKey:UUDAMDVQRQNNHZ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutamate Receptor 1 (GluR1) also known as AMPA Receptor along with other subtypes like KA1 GluK2 GluA3 and GluA4 is a protein complex responsible for mediating fast synaptic transmission in the central nervous system. These receptors are ionotropic glutamate receptors and they are activated when the neurotransmitter glutamate binds to them. The activation allows the flow of sodium and calcium ions through the channel leading to excitatory postsynaptic potentials. The mass of AMPA receptors varies commonly around 100 kDa. These receptors are expressed in different regions of the brain for example the hippocampus and cerebral cortex which are areas important for memory processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese receptors play an essential role in synaptic plasticity which is the cellular basis for learning and memory. They may form part of larger protein complexes that influence their trafficking and function in the neuronal membrane. The AMPA receptors interact with auxiliary proteins like stargazin which help in proper surface expression and synaptic localization. The ionotropic glutamate receptors establish the initial synaptic response setting off further events in excitatory neurotransmission that contribute to cognitive functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nGlutamate receptors like AMPA and kainate subtypes are involved in the glutamatergic signaling pathway. This pathway plays a pivotal role in propagating excitatory signals across neurons. Important proteins related to this pathway include NMDA receptors which in combination with AMPA receptors modulate synaptic strength and plasticity. The intracellular signaling cascade resulting from receptor activation can also involve calcium-calmodulin-dependent protein kinase (CaMKII) an important player in the longer-term changes in synaptic efficacy.\u003cbr\u003e\nThese receptors have significant involvement in neurodegenerative diseases like Alzheimer's and neurological conditions such as epilepsy. In Alzheimer's the improper regulation of synaptic AMPA receptor expression may lead to synaptic failure and cognitive impairment. Dysregulation of AMPA receptors is also associated with epileptic activity where excessive excitation can result in seizures. Understanding these interactions might offer potential therapeutic targets; for instance modulating NMDA and AMPA receptor activity can prove valuable in alleviating symptoms or slowing disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847503204521,"sku":"ab146679","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab146679","provider":"Iright","version":"1.0","type":"link"}