{"product_id":"abcam-ab146939","title":"Abcam, ab146939, NVS-PAK1-1, PAK1 inhibitor","description":"\u003cp\u003eSize: 5mg \/ 10mg\u003cbr\u003e\nMW 479.93 g\/mol, Purity \u0026gt;98%. NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1. It has an IC 50  value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an  in vitro  assay. It is more than 50-fold more active against PAK1 than against PAK2. NVS-PAK1-1 is highly selective in a panel of 442 kinases. NVS-PAK1-1 potently inhibits PAK1 autophosphorylation in cell-based assays.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1783816-74-9,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:LyophilizedSee storage information,\u003cbr\u003e\nMolecular weight:479.93 g\/mol,\u003cbr\u003e\nMolecular formula:C23H25ClF3N5O,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 100 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiological description:NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1. It has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro assay. It is more than 50-fold more active against PAK1 than against PAK2. NVS-PAK1-1 is highly selective in a panel of 442 kinases. NVS-PAK1-1 potently inhibits PAK1 autophosphorylation in cell-based assays.,\u003cbr\u003e\nIsomeric smiles:O=C(NC(C)C)N4CC[C@H](NC1=NC3CC(F)CCC3N(CC(F)F)C2CCC(CL)CC12)C4,\u003cbr\u003e\nInChi:InChI=1S\/C23H25ClF3N5O\/c1-13(2)28-23(33)31-8-7-16(11-31)29-22-17-9-14(24)3-5-19(17)32(12-21(26)27)20-6-4-15(25)10-18(20)30-22\/h3-6,9-10,13,16,21H,7-8,11-12H2,1-2H3,(H,28,33)(H,29,30)\/t16-\/m0\/s1,\u003cbr\u003e\nIUPAC Name:(S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847501566121,"sku":"ab146939","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab146939","provider":"Iright","version":"1.0","type":"link"}