{"product_id":"abcam-ab14715","title":"Abcam, ab14715, Anti-SDHA antibody [2E3GC12FB2AE2]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-SDHA antibody [2E3GC12FB2AE2] (ab14715) is a mouse monoclonal antibody detecting SDHA in  Western Blot, Flow Cytometry, IHC-P, IHC-Fr . Suitable for  Cow, Human, Mouse, Rat . - Clone 2E3GC12FB2AE2 is the most cited clone to SDHA - KO validated for confirmed specificity - Over 460 publications - Trusted since 2004\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:2E3GC12FB2AE2,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Cow, Human,\u003cbr\u003e\nApplications:WB, IHC-P, IHC-Fr, Flow Cyt, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-SDHA antibody [2E3GC12FB2AE2] (ab14715) is a House Mouse Monoclonal antibody and is validated for use in Flow Cyt, ICC, IHC-Fr, IHC-P, WB in human, rat samples.\u003cbr\u003e\nAnti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has been cited over 460 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAbcams high quality validation processes ensure Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has high sensitivity and specificity.\u003cbr\u003e\nThe specificity of Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has been confirmed by testing in knockout samples.\u003cbr\u003e\nAnti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has 23 independent reviews from customers.\u003cbr\u003e\nAnti-SDHA antibody [2E3GC12FB2AE2] (ab14715) specifically detects SDHA (UniProt ID: P31039; Molecular weight: 68kDa) and is sold in 100 ug selling sizes.\u003cbr\u003e\nAntibody clone 2E3GC12FB2AE2 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 594, HRP (\u003cbr\u003e\nab154473\u003cbr\u003e\n, ab17172,\u003cbr\u003e\nab198493\u003cbr\u003e\nSDHA (FP), a subunit of succinate dehydrogenase, is a crucial mitochondrial enzyme involved in the Krebs cycle and electron transport chain. The SDHA molecular weight is approximately 72 kDa, and it plays a vital role in cellular energy production. The FP antibody is essential for studying SDHA's function and its role as a tumor suppressor. Abnormal SDHA levels are linked to various diseases, including hereditary paragangliomas, pheochromocytomas, and certain cancers. Monitoring SDHA can provide valuable insights into disease mechanisms and potential therapeutic targets.\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-IgG fraction, Purification notes-Near homogeneity as judged by SDS-PAGE. The antibody was produced invitro using hybridomas grown in serum-free medium, and then purified bybiochemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSuccinate dehydrogenase complex flavoprotein subunit A (SDHA) also known as complex II Fp or SDH2 plays an important role in the mitochondrial electron transport chain and the tricarboxylic acid (TCA) cycle. It functions as a flavoprotein oxidoreductase catalyzing the oxidation of succinate to fumarate. With a molecular mass of approximately 72 kDa SDHA is expressed in the inner mitochondrial membrane of eukaryotic cells where it is a core component of the succinate dehydrogenase complex (SDHC). The complex is essential for cellular respiration and energy production.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSDHA participates in the TCA cycle by accepting electrons from succinate which it donates to the coenzyme Q in the electron transport chain. This essential role connects SDHA to the regulation of ATP production in cells. SDHA operates as part of the larger succinate dehydrogenase (SDH) complex which includes other subunits such as SDHB SDHC and SDHD. This structurally integrated multisubunit complex influences mitochondrial integrity and cellular energy homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSDHA is deeply involved in the TCA cycle and oxidative phosphorylation pathway. As a part of these pathways it links to other critical enzymes such as fumarase and aconitase working in concert to drive the conversion of biochemical fuel into usable cellular energy. Its interactions with coenzyme Q and cytochrome complex enzymes are important for electron flow and proton gradient formation across the mitochondrial membrane. Such interactions are central to cellular respiration and energy generation.\u003cbr\u003e\nMutations in SDHA correlate with various mitochondrial diseases and cancer syndromes. Specifically SDHA mutations have an association with Leigh syndrome and certain types of mitochondrial complex II deficiency. These mutations disrupt the function of the SDH complex causing metabolic imbalances and energy production issues. Furthermore the integral interaction of SDHA with other SDH subunits means that alterations can impact this entire enzymatic complex with implications for cellular respiration and disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844124168361,"sku":"ab14715","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab14715","provider":"Iright","version":"1.0","type":"link"}