{"product_id":"abcam-ab14781","title":"Abcam, ab14781, Anti-AC6 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal AC6 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Rat Adenylate cyclase type 6 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat, Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Rat Adenylate cyclase type 6 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q03343\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The affinity-purified antibodies are purified on antigen-sepharose affinity column and supplied in antibody stabilization buffer containing preservatives with low viscosity and cryogenic properties., Storage buffer-Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAdenylate Cyclase 6 (AC6) also known as ADCY6 is an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP) and pyrophosphate. This enzyme belongs to the class of adenylyl cyclases and has a mass of approximately 130 kDa. AC6 is widely expressed in mammalian tissues most notably in the heart brain and lungs. It plays a significant role in cellular signal transduction processes responding to G protein-coupled receptor (GPCR) activation by regulating intracellular cAMP levels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAC6 is extensively involved in cellular signaling mechanisms. It often exists as part of a larger signaling complex interacting with G proteins and other regulatory molecules. The elevation of cAMP by AC6 influences diverse physiological processes including heart rate regulation and neurotransmitter release. This establishes the importance of AC6 in both cardiac function and neural activities highlighting its impact on normal physiological states and potential pathological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe AC6 enzyme is integral to the activation of the cAMP-dependent pathway and further influences the protein kinase A (PKA) signaling cascade. Through these pathways AC6 connects with proteins such as Gs alpha subunits and downstream elements like PKA substrates. AC6's activity helps modulate diverse cellular functions by altering cAMP concentrations which is critical for transmitting signals from GPCRs to physiological responses.\u003cbr\u003e\nAC6 has links to heart failure and depression. Altered AC6 function can disrupt normal cardiac physiology leading to heart failure due to improper adrenergic signaling. Similarly deviations in AC6 activity have associations with depression likely through its role in neurotransmitter signaling in the brain. In these contexts AC6 interfaces with other protein targets such as beta-adrenergic receptors in the heart and serotonin receptors in the brain demonstrating its impact on disease-related pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850150039721,"sku":"ab14781","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab14781","provider":"Iright","version":"1.0","type":"link"}