{"product_id":"abcam-ab150431","title":"Abcam, ab150431, Anti-SH3GL1 + SH3GL2 + SH3GL3 antibody [EPR10215(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SH3GL2 antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10215(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSH3GL2 also known as Endophilin A1 is a protein that plays an important role in membrane dynamics during endocytosis. It has a molecular weight of approximately 41 kDa. Mechanically SH3GL2 binds to lipids and helps in membrane curvature due to its BAR domain. This protein is highly expressed in neuronal tissues where it participates in synaptic vesicle endocytosis. It interacts with other proteins via its SH3 domain facilitating the assembly of protein complexes involved in these cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSH3GL2 is involved in synaptic vesicle recycling an important process for neurocommunication. It is part of a complex that includes proteins such as dynamin and synaptojanin. It ensures the rapid turnover of synaptic vesicles by mediating their endocytosis and recycling back to the synaptic terminal. This function helps in maintaining efficient synaptic transmission essential for neuronal communication and plasticity.\u003cbr\u003e\nPathways\u003cbr\u003e\nSH3GL2 is involved in the clathrin-mediated endocytosis pathway. This pathway is critical for the retrieval of synaptic vesicles in neurons. SH3GL2 works closely with clathrin and dynamin to facilitate the budding and scission of vesicles from the plasma membrane. In addition SH3GL2 also interacts within the synaptic vesicle cycle ensuring the availability of vesicles for neurotransmitter release.\u003cbr\u003e\nSH3GL2 has been linked to neurodegenerative diseases such as Parkinson's disease. Its interaction with proteins like alpha-synuclein suggests its role in the pathogenesis of this disorder. Altered SH3GL2 function may disrupt normal synaptic vesicle dynamics contributing to neuronal dysfunction. Furthermore aberrant SH3GL2 expression or function may also be involved in schizoaffective disorders where its interaction with synaptojanin plays a role in synaptic dysfunction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850345468073,"sku":"ab150431","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab150431","provider":"Iright","version":"1.0","type":"link"}