{"product_id":"abcam-ab150525","title":"Abcam, ab150525, Anti-T1R3 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal T1R3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TAS1R3.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TAS1R3. The exact immunogen used to generate this antibody is proprietary information.Q7RTX0,\u003cbr\u003e\nSpecificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nT1R3 also known as TAS1R3 functions as a taste receptor. Weighing around 90kDa T1R3 is part of the G protein-coupled receptor family. It is largely expressed in the taste buds on the tongue and some extraoral tissues. T1R3 partners with TAS1R1 or TAS1R2 to detect umami and sweet taste respectively. This protein is critical in the detection and signaling of taste perceptions in the gustatory pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nT1R3 plays a role in nutrient sensing and metabolic regulation. As part of a receptor complex T1R3 partners with TAS1R2 to form a sweet taste receptor and pairs with TAS1R1 to form an umami receptor. This pairing occurs at the cell surface in the taste buds and is vital for the recognition of specific ligands like amino acids and sugars. T1R3's ability to sense nutrients impacts digestive processes and energy balance.\u003cbr\u003e\nPathways\u003cbr\u003e\nT1R3 involvement extends to signaling pathways related to taste signaling and energy homeostasis. T1R3 activates taste GPCR pathways which contribute to neurotransmitter release in taste perceptions. It connects to the phosphatidylinositol signaling system pathway impacting cellular processes through interaction with proteins like PLCβ2. T1R3 also interfaces with cellular mechanisms influenced by serotonin and glutamate receptors.\u003cbr\u003e\nT1R3 has a connection to metabolic diseases including obesity and diabetes. It influences glucose metabolism and energy intake linking it to these conditions. T1R3 has interactions with other proteins such as leptin which is involved in body weight regulation. Impairment or alterations in T1R3 function can correlate with dietary-related disorders impacting disease progression through metabolic pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850071298217,"sku":"ab150525","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab150525","provider":"Iright","version":"1.0","type":"link"}