{"product_id":"abcam-ab150663","title":"Abcam, ab150663, Congo Red Stain Kit (Amyloid Stain)","description":"\u003cp\u003eSize: 100Test\u003cbr\u003e\nCongo Red Stain Kit \/ Amyloid Stain Kit ab150663 is used for the histological visualization of amyloid in tissue sections.\u003cbr\u003e\nKey facts\u003cbr\u003e\nSample types:Tissue sections\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe Congo Red Stain Kit \/ Amyloid Stain Kit is intended for use in the histological visualization of amyloid in tissue sections. Examination under a polarizing microscope results in green birefringence of amyloid.\u003cbr\u003e\nOther products for staining tissue sections\u003cbr\u003e\nFind more kits and reagents in the\u003cbr\u003e\nspecial stains guide\u003cbr\u003e\n, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the\u003cbr\u003e\nIHC kits and reagents guide\u003cbr\u003e\nStaining Interpretation\u003cbr\u003e\nAmyloid\u003cbr\u003e\nRed to Pink\u003cbr\u003e\nErythorcytes\u003cbr\u003e\nLight Orange\u003cbr\u003e\nEosdinophil Granules\u003cbr\u003e\nOrange to Red\u003cbr\u003e\nNuclei\u003cbr\u003e\nControl Tissue\u003cbr\u003e\nFreshly cut sections containing amyloid.\u003cbr\u003e\nCut sections 6-12 microns to show smaller amyloid deposits.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Ambient\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAmyloid refers to protein aggregates known for their beta-sheet structure. These aggregates accumulate extracellularly in tissues and organs. The term ‘amyloid’ encompasses a collection of proteins including amyloid beta and amyloid precursor protein which can weigh around 4 kDa to several hundred kDa depending on the type. Amyloid deposits occur in the brain and other organs. Detected through methods like Congo red staining these aggregates are important in diagnosing amyloidosis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe proteins that form amyloid aggregates affect cellular function by altering normal protein conformation leading to toxicity. Amyloid can form complexes with other proteins which impact cell membranes and disrupt cellular homeostasis. These alterations trigger inflammatory responses and cellular stress pathways further damaging affected tissues. Understanding amyloid proteins provides insight into their role in disease states.\u003cbr\u003e\nPathways\u003cbr\u003e\nAmyloid proteins interplay with several signaling cascades notably the MAPK and NF-kB pathways. Amyloid precursor protein processed to form amyloid beta significantly influences these pathways mediating cell death and inflammation. Proteins such as tau also interact with amyloid-related pathways impacting cellular transport mechanisms. These interactions highlight amyloid's role in cell signaling and pathology.\u003cbr\u003e\nAmyloid proteins are strongly associated with Alzheimer's disease and systemic amyloidosis. The accumulation of amyloid beta aggregates in the brain marks the pathology of Alzheimer's closely linked with tau protein hyperphosphorylation and neurofibrillary tangles. In systemic amyloidosis amyloid deposition occurs in various tissues causing organ dysfunction. The relation of target proteins like apolipoprotein E to amyloid further elucidates its implications in neurodegenerative and systemic conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843644838057,"sku":"ab150663","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab150663","provider":"Iright","version":"1.0","type":"link"}