{"product_id":"abcam-ab150820","title":"Abcam, ab150820, Anti-USH1G antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal USH1G antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USH1G aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human USH1G aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q495M9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUSH1G also known as SANS (Scaffold protein containing Ankyrin Repeats and SAM domain) plays a mechanical role in cellular structures and processes. This protein has a molecular mass of approximately 54 kDa. It is expressed in the inner ear retina and possibly other tissues suggesting a broad role in sensory functions. USH1G is involved in maintaining protein interactions important for cellular architecture and function contributing to the organization of the cytoskeleton.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUSH1G acts as a scaffold protein that assists in forming protein complexes vital for mechanosensory hair cells in the ear. It participates in linking proteins such as harmonin and the myosin motor proteins forming part of a ternary complex that is essential within the stereocilia of hair cells. This complex ensures proper hair cell mechanoelectrical transduction which is necessary for sound and balance perception.\u003cbr\u003e\nPathways\u003cbr\u003e\nUSH1G operates within key mechanotransduction pathways of the sensory cells. It interacts significantly with the PDZD7 and harmonin proteins providing critical support for these pathways. The PDZD7 protein in particular is also a part of the Usher protein interactome which is essential for developing and maintaining hair cell function in the auditory system.\u003cbr\u003e\nMalfunctions or mutations in the USH1G gene associate with Usher syndrome type 1G a condition leading to hearing loss and visual impairments. The protein also relates to retinitis pigmentosa through its role in the Usher protein complex which involves other proteins like cadherin-23. Disruptions in the interactions among these proteins often result in sensory deficits characteristic of these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854159007913,"sku":"ab150820","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab150820","provider":"Iright","version":"1.0","type":"link"}