{"product_id":"abcam-ab151248","title":"Abcam, ab151248, Anti-ZNHIT1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ZNHIT1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNHIT1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human ZNHIT1.O43257\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZNHIT1 also known as Zinc finger HIT-type containing 1 is a protein that plays a role in the assembly of multiprotein complexes. It has a molecular mass of approximately 29 kDa. This protein is found expressed in various tissues including the brain heart and liver suggesting its involvement in a range of biological functions. ZNHIT1 contains zinc finger motifs which are key for its interaction with other proteins facilitating its mechanical role in cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe interaction of ZNHIT1 with other protein units forms part of the histone and transcription machinery. It is a component of the U3 small nucleolar ribonucleoprotein (snoRNP) complex which is essential for the biogenesis of ribosomes. Through its zinc finger domains ZNHIT1 interacts with proteins such as NOLC1 aiding in the functional assembly of ribosome-related structures. The activity of ZNHIT1 within this context points to its importance in maintaining protein synthesis and gene regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nZNHIT1 is involved in the metabolic and cellular processes of ribosome assembly and gene expression. In the context of these pathways its interaction with NOLC1 facilitates alterations in nucleolar activity which can impact protein synthesis. ZNHIT1 can influence pathways such as the assembly of the pre-rRNA complex and is also linked to transcriptional regulation alongside proteins like SMARCC1 within epigenetic modification routes.\u003cbr\u003e\nZNHIT1 has connections with certain cancers and neurodegenerative conditions. Its regulatory roles in gene expression and ribosome production can contribute to pathologies like hepatocellular carcinoma where aberrations in protein synthesis are common. Altered function or expression of ZNHIT1 can also associate with neurological disorders interconnected through proteins such as AATF which is implicated in neuronal survival. Understanding ZNHIT1’s involvement in these pathways can offer insights into potential therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854189154473,"sku":"ab151248","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab151248","provider":"Iright","version":"1.0","type":"link"}