{"product_id":"abcam-ab151491","title":"Abcam, ab151491, Anti-PIBF antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PIBF antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PIBF1 aa 450-700.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PIBF1 aa 450-700. The exact immunogen used to generate this antibody is proprietary information.Q8WXW3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe progesterone-induced blocking factor (PIBF) is a protein with a molecular mass of approximately 90 kDa. It has important roles linked to cell division and immune response regulation. PIBF is produced in larger quantities in pregnancy tissues particularly by decidual and trophoblastic cells but normal lymphocytes also express it when stimulated by progesterone. Researchers often study its activity because of its potential relevance in pregnancy and immune system interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nResearchers already documented that PIBF plays a role in modulating immune responses during pregnancy. It acts as part of a complex involving progesterone and cytokines working to prevent the mother's immune system from rejecting the fetus. PIBF achieves this by influencing the Th1\/Th2 cytokine balance increasing anti-inflammatory cytokines and decreasing pro-inflammatory cytokines like IL-6 and IL-12. This helps to maintain a tolerogenic environment during pregnancy.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe PIBF significantly affects pathways involving immune regulation and inflammation. It interacts with the hormonal pathway of progesterone linking it to the immune-modulatory functions controlled by cytokine action. The balance between these pathways ensures immune tolerance in the placenta. PIBF also shares a functional pathway with proteins such as interleukin-10 (IL-10) as they both modulate immune responses to support successful pregnancies.\u003cbr\u003e\nPIBF has significant associations with pregnancy-related conditions and certain cancers. Abnormal PIBF levels may relate to pregnancy complications such as recurrent spontaneous abortion where immune tolerance gets disrupted. Additionally PIBF can impact tumor growth because it promotes an immunosuppressive environment similar to that observed in pregnancy potentially benefiting malignant cells. This connection suggests that PIBF along with related proteins like IL-10 could serve as a target for therapeutic interventions in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850079686825,"sku":"ab151491","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab151491","provider":"Iright","version":"1.0","type":"link"}