{"product_id":"abcam-ab152750","title":"Abcam, ab152750, Recombinant Human TLE4 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human TLE4 protein is a Human Full Length protein, in the 1 to 773 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q04727,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTransducin-like enhancer of split 4 (TLE4) is a transcriptional corepressor involved in the regulation of gene expression. It is also known as ESG (Enhancer of split groucho) or GRG4. TLE4 belongs to the Groucho\/TLE protein family which shares a general structure characterized by WD40 repeats. The protein has a molecular mass of about 82 kDa. TLE4 expresses in several tissues including the brain heart and peripheral blood leukocytes indicating its broad functional importance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTLE4 participates in the repression of transcription by forming a multiprotein complex. It acts as a corepressor that interacts with various transcription factors often modulating the expression of genes involved in developmental processes. TLE4 commonly partners with transcription factors from the basic helix-loop-helix (bHLH) family which play a significant role in the regulation of neuronal and muscular development. The repression activity of TLE4 makes it a temporal regulator helping maintain and coordinate gene expression during cellular differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nTLE4 functions within the Wnt signaling and Notch signaling pathways. Both of these pathways are important for cell fate determination and organ development. In the Wnt pathway TLE4 interacts with beta-catenin to modulate transcriptional activity contributing to cellular responses to external signals. In the Notch signaling pathway TLE4 associates with core transcription factors like CSL (CBF1\/Suppressor of Hairless\/Lag1) to regulate the expression of Notch target genes facilitating diverse developmental processes.\u003cbr\u003e\nTLE4 has links to hematological malignancies and neurological conditions. Its dysregulation can contribute to conditions like acute myeloid leukemia (AML) alongside proteins such as RUNX1 which play a role in hematopoiesis and myeloid lineage development. Additionally altered TLE4 expression has associations with neurodevelopmental disorders as its interaction with key proteins in neuronal differentiation is disturbed affecting neuronal function and development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843898233001,"sku":"ab152750","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab152750","provider":"Iright","version":"1.0","type":"link"}