{"product_id":"abcam-ab153567","title":"Abcam, ab153567, Recombinant Human CREB3L1\/OASIS protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human CREB3L1\/OASIS protein is a Human Full Length protein, in the 1 to 519 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96BA8,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as CREB3L1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCREB3L1 also known as OASIS is a transcription factor with a significant role in various cellular functions. It belongs to the CREB\/ATF family and has a molecular mass of approximately 55 kDa. This protein is mainly expressed in the endoplasmic reticulum (ER) of astrocytes bone cells and certain cancerous cells. CREB3L1 regulates gene expression in response to stress conditions related to the ER making it a focal point of interest in cellular stress response studies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCREB3L1 is involved in the regulation of unfolded protein response (UPR). It activates genes responsible for protein folding processing and secretion ensuring proper cellular function. CREB3L1 or OASIS generally does not form complexes but operates predominantly on its own. It serves as a bridge between stress signals received by the ER and the transcriptional machinery of the nucleus thereby playing a critical role in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis transcription factor integrates signals within the unfolded protein response and bone metabolism pathways. CREB3L1 regulates the transcription of genes involved in ER stress response linking it to key proteins such as BiP and CHOP. Additionally CREB3L1 influences osteocalcin transcription tying it to bone formation and matrix production pathways. It directly affects cellular adaptation by controlling gene expression related to ER stress and osteogenesis.\u003cbr\u003e\nCREB3L1 links closely to osteogenesis imperfecta and certain aspects of glioblastoma. Its regulatory function in osteocalcin expression connects it with bone fragility conditions necessitating in-depth research into CREB3L1-related pathways for potential therapeutic targets. In glioblastoma CREB3L1 expression correlates with tumor cell response to stress making it an essential protein for understanding the ER stress-related mechanisms in cancer progression. Connections with proteins like osteocalcin in bone disorders and BiP in stress responses highlight its importance in disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843975631017,"sku":"ab153567","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab153567","provider":"Iright","version":"1.0","type":"link"}