{"product_id":"abcam-ab154189","title":"Abcam, ab154189, Anti-KBTBD8 antibody [EPR10698(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal KBTBD8 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10698(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKBTBD8 also known as Kelch repeat and BTB domain-containing protein 8 serves a mechanical role in the stabilization and ubiquitination processes. It functions as an adapter protein connecting specific substrates to a core ubiquitin ligase complex facilitating substrate degradation through the proteasome. KBTBD8 has an approximate mass of 69 kDa. In terms of expression KBTBD8 is found in various tissues with significant levels observed in the brain and developing tissues indicating its importance in developmental processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKBTBD8 acts in cellular regulation and developmental processes. It is involved in the formation of a complex that mediates specific substrate recognition essential for precise protein turnover and cellular homeostasis. Evidence shows its role in neural tube development by regulating cytoskeletal dynamics emphasizing its contribution to embryonic morphogenesis. KBTBD8 activity requires interaction with other molecules in the ubiquitination pathway ensuring regulated proteolysis necessary for normal cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of KBTBD8 extends into the ubiquitin-proteasome pathway and cytoskeletal regulation pathways. An important pathway includes its association with CRL4 E3 ligase complex a critical component that modulates cell cycle progression and response to DNA damage. Through these pathways KBTBD8 interacts with proteins such as CUL4 and DDB1 which play essential roles in maintaining genomic stability and cellular integrity.\u003cbr\u003e\nKBTBD8 relates to conditions like neural tube defects and certain cancers. Its abnormal expression or malfunction may contribute to improper embryonic development manifesting as neural tube defects. Furthermore disrupted regulation of the ubiquitination pathway involving KBTBD8 can lead to oncogenesis with proteins such as p53 being affected through altered ubiquitin-mediated processes. These associations highlight the significance of KBTBD8 in maintaining cellular and developmental equilibrium.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850442625193,"sku":"ab154189","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab154189","provider":"Iright","version":"1.0","type":"link"}