{"product_id":"abcam-ab155460","title":"Abcam, ab155460, Mouse TCA-3 ELISA Kit (CCL1)","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nMouse TCA-3 ELISA Kit (CCL1) is a Sandwich (quantitative) ELISA for the measurement of Mouse TCA-3 (CCL1) in Mouse in Biofluids, Cell Culture Media samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Plasma, Cell culture supernatant, Serum,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:\u0026lt; 30 pg\/mL,\u003cbr\u003e\nRange:0.033 - 8 ng\/mL,\u003cbr\u003e\nAssay Platform:Microplate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAbcam's TCA-3 (CCL1) Mouse ELISA (Enzyme-Linked Immunosorbent Assay) kit is an\u003cbr\u003e\nin vitro\u003cbr\u003e\nenzyme-linked immunosorbent assay designed for the quantitative measurement of TCA-3 (CCL1) in mouse serum, plasma and cell culture supernatants.\u003cbr\u003e\nThis assay employs an antibody specific for mouse TCA-3 coated on a 96-well plate. Standards and samples are pipetted into the wells and TCA-3 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-mouse TCA-3 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and colour develops in proportion to the amount of TCA-3 bound. The Stop Solution changes the colour from blue to yellow, and the intensity of the colour is measured at 450 nm.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTCA-3 also known as CCL1 is a chemokine protein with an approximate molecular weight of 10 kDa. It belongs to the CC chemokine family and functions as a signaling molecule in immune responses. TCA-3 exhibits high expression in activated T lymphocytes macrophages and dendritic cells. This protein plays a role in the regulation of immune cell trafficking by interacting with specific G-protein-coupled receptors on the surfaces of target cells influencing cell movement towards the sites of inflammation or injury.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTCA-3 impacts the immune system by contributing to cytokine receptor-mediated signaling pathways. It is involved in promoting T cell activation and differentiation facilitating immune surveillance and response. TCA-3 operates not as part of a complex but mainly influences cell behavior through its receptor CCR8. This interaction modulates key functions such as cell migration and immune response regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nTCA-3 participates significantly in the chemokine signaling pathway and the innate immune response. It is vital in mediating inflammatory responses allowing TCA-3 to direct the movement of cells to inflammation sites. TCA-3 has functional links with proteins like CCR8 its receptor enabling T cells to respond selectively to TCA-3 signals. These associations highlight its role in shaping the body's ability to respond to immune challenges.\u003cbr\u003e\nThe dysregulation of TCA-3 has implications in conditions like rheumatoid arthritis and certain allergic reactions. Elevated levels of TCA-3 can lead to excessive recruitment of inflammatory cells exacerbating disease symptoms. Through its receptor CCR8 TCA-3 may influence disease progression and severity by altering immune cell behavior. Understanding TCA-3's role and connections in these disorders can inform therapeutic strategies targeting immune and inflammatory processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855642251433,"sku":"ab155460","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab155460","provider":"Iright","version":"1.0","type":"link"}