{"product_id":"abcam-ab155802","title":"Abcam, ab155802, Anti-RPL15\/L10 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal RPL15\/L10 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RPL15 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RPL15 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.P61313\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRPL15 also known as ribosomal protein L15 or L10 is involved in protein synthesis as part of the ribosomal subunit. It has a mass of approximately 24 kDa. RPL15 is expressed in various tissues showing high levels in rapidly dividing cells such as those in the bone marrow and some cancer tissues. As a component of the large 60S ribosomal subunit it directly participates in the assembly and function of ribosomes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPL15 acts in concert with other ribosomal proteins to ensure proper translation of mRNA into proteins. It is part of the ribosome a complex and essential structure for cellular function and growth. The ribosome consists of RNA and proteins where RPL15 plays a role in maintaining the integrity and functionality of this complex. Without RPL15 cells would experience impaired protein synthesis which can significantly impact cell viability and proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nRPL15 is significant in the mRNA translation pathway a core process involved in generating cellular proteins. It connects with various other ribosomal proteins such as RPL6 and RPL13 to ensure accurate and efficient translation. Another pathway where RPL15 has a role includes the signal recognition particle (SRP)-dependent co-translational protein targeting to membrane which directs protein synthesis to specific cellular locations illustrating its integration into cellular machinery.\u003cbr\u003e\nRPL15 has shown a connection to cancer particularly in its overexpression in certain tumors where its high levels can drive increased protein synthesis fostering rapid tumor growth. Furthermore RPL15's relationship with ribosomal protein S6 (RPS6) another key player in protein synthesis highlights its involvement in pathways that can lead to ribosomal biogenesis disorders a group of diseases often related to cell growth and division abnormalities like certain anemias.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854358171817,"sku":"ab155802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab155802","provider":"Iright","version":"1.0","type":"link"}