{"product_id":"abcam-ab157866","title":"Abcam, ab157866, Recombinant Human AP1B1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human AP1B1 protein is a Human Full Length protein, in the 1 to 939 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q10567,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAP1B1 also known as Adaptor-related protein complex 1 subunit beta-1 is involved in mechanical functions related to protein sorting and vesicle formation. It has a molecular mass of approximately 105 kDa. This protein forms part of the AP-1 complex which is present in various cell types particularly expressed in epithelial tissues. AP1B1 functions as an important component in clathrin-coated vesicle transport assisting in the selection of cargo that is transported between the trans-Golgi network and endosomes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of the AP1B1 extends to ensuring proper cellular trafficking maintaining cell polarity and function within epithelial cells. As part of the AP-1 complex it interacts with other subunits to facilitate the budding of vesicles a critical step in cell function and homeostasis. AP1B1's involvement in intracellular transport underlines its significance in cellular processes that require precise protein localization and distribution.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe AP1B1 protein plays an essential role in the clathrin-mediated endocytosis and post-Golgi trafficking pathways. It operates alongside other proteins like clathrin and AP-1 γ subunit coordinating the transport of receptors and other protein complexes to their specific intracellular destinations. This molecular coordination supports processes such as receptor recycling and lysosomal targeting within the cell environment.\u003cbr\u003e\nErrors in AP1B1 function can link to specific medical conditions such as Hermansky-Pudlak syndrome and neurodegenerative diseases. In these conditions alterations in the AP1B1 protein may disrupt normal vesicle trafficking and protein sorting processes. The disorder-related disruption illustrates how AP1B1 potentially interacting with proteins like the lysosomal-associated membrane protein 2 can impact cellular homeostasis and lead to systemic effects in tissue biology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843964981417,"sku":"ab157866","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab157866","provider":"Iright","version":"1.0","type":"link"}