{"product_id":"abcam-ab159276","title":"Abcam, ab159276, Recombinant Human Prostaglandin F2 alpha Receptor\/PTGFR protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human Prostaglandin F2 alpha Receptor\/PTGFR protein is a Human Full Length protein, in the 1 to 359 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P43088,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as Prostaglandin F2 alpha Receptor.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Prostaglandin F2 alpha Receptor also known as PTGFR is a G-protein-coupled receptor with a molecular mass of about 66 kDa. This receptor plays an essential role in mediating the effects of prostaglandin F2 alpha (PGF2α) a lipid compound involved in various physiological processes. The receptor is mainly expressed in tissues such as the uterus eye and vascular smooth muscle. Its localization allows it to actively participate in reproductive functions and other biological activities in these tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProstaglandin F2 alpha Receptor functions as part of the prostanoid receptor family which mediates diverse physiological responses. PGF2α binding to the PTGFR induces intracellular signaling cascades that lead to smooth muscle contraction and modulation of inflammation. The receptor is not known to be part of any higher-order complex but interacts with intracellular signaling molecules to exert its effects. Its activity is important in processes such as luteolysis and modulation of intraocular pressure.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Prostaglandin F2 alpha Receptor is involved in key regulatory pathways like the prostaglandin signaling pathway and the smooth muscle contraction pathway. Within the prostaglandin signaling pathway PTGFR works with proteins such as phospholipase C to increase intracellular calcium levels leading to smooth muscle contraction. Its role in these pathways highlights its function in reproductive cycles and maintenance of cardiovascular health.\u003cbr\u003e\nThe Prostaglandin F2 alpha Receptor has associations with conditions such as glaucoma and dysmenorrhea. In glaucoma the receptor's role in modulating intraocular pressure links it to elevated pressure and optic nerve damage. Similarly dysmenorrhea involves excessive uterine muscle contractions where PTGFR-mediated signaling becomes heightened. The receptor's interaction with other proteins like cyclooxygenase-2 (COX-2) exacerbates these conditions by influencing prostaglandin production and signaling.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843967897769,"sku":"ab159276","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab159276","provider":"Iright","version":"1.0","type":"link"}