{"product_id":"abcam-ab160295","title":"Abcam, ab160295, Recombinant Human CH25H protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human CH25H protein is a Human Full Length protein, in the 1 to 272 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:O95992,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CH25H protein also known as cholesterol 25-hydroxylase catalyzes the conversion of cholesterol into 25-hydroxycholesterol. This enzyme has a mass of approximately 33 kDa. It expresses widely in tissues but its level of expression is highest in macrophages and the liver. The protein is part of the enzymatic group that modulates lipid homeostasis and is integral to host defense mechanisms.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCholesterol 25-hydroxylase plays a significant role in lipid metabolism and immune regulation. It produces 25-hydroxycholesterol a potent oxysterol which exerts effects on lipid metabolic processes and immune cell signaling. While not part of a large multiprotein complex CH25H's activity impacts cellular cholesterol levels and potentially influences the production of certain signaling molecules.\u003cbr\u003e\nPathways\u003cbr\u003e\nCholesterol 25-hydroxylase contributes to the regulation of lipid metabolic pathways and innate immune responses. Within the lipid metabolism pathway CH25H interacts with proteins like LXR (liver X receptor) affecting cholesterol homeostasis. The enzyme also influences immune regulation by altering the production of signaling molecules that modulate the interferon response affecting pathways related to inflammation and innate immunity.\u003cbr\u003e\nCholesterol 25-hydroxylase has connections to atherosclerosis and viral infections. In the context of atherosclerosis its function in regulating cholesterol levels can influence plaque formation in arteries. The protein's involvement in immune response modulation links it to the body's defense against viral infections. Additionally CH25H's activity interacts with proteins involved in the immune response such as IFN-induced proteins to mount an antiviral state.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843962392745,"sku":"ab160295","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab160295","provider":"Iright","version":"1.0","type":"link"}