{"product_id":"abcam-ab160709","title":"Abcam, ab160709, Recombinant Human RABGAP1L\/HHL protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human RABGAP1L\/HHL protein is a Human Fragment protein, in the 1 to 110 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q5R372,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as RABGAP1L.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRABGAP1L also known as HHL is a GTPase-activating protein (GAP) that targets Rab GTPases which are important regulators of intracellular vesicle transport. The exact mass of the RABGAP1L protein is not well-documented but it is expressed in various tissues with significant presence in brain among others. This distribution suggests RABGAP1L's involvement in diverse cellular processes especially those requiring active vesicle trafficking and membrane dynamics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein acts as a regulatory molecule modulating the activity of Rab GTPases by accelerating the hydrolysis of GTP to GDP. This action helps switch the GTPases from an active to an inactive state which is vital for the spatial and temporal regulation of vesicular trafficking. RABGAP1L frequently associates with multiprotein complexes contributing to its regulatory functions in trafficking and signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein plays a significant role in the endocytosis and exocytosis pathways that are vital for recycling membrane and macromolecules. RABGAP1L interacts with proteins like Rab11 in the endosomal recycling compartment which is essential for the efficient sorting and recycling of transmembrane proteins. These interactions highlight its involvement in the cellular management of vesicular transport and suggest its regulatory influence on several cellular processes.\u003cbr\u003e\nRABGAP1L links to conditions such as neurological disorders and cancer where dysregulation of vesicular trafficking is a common factor. For instance its interaction with proteins involved in synaptic vesicle trafficking possibly associates it with certain neurodegenerative disorders. It also relates with oncogenic processes through its influence on the transport pathways mirroring dysfunctions seen in other regulatory proteins involved in cancer pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843977466025,"sku":"ab160709","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab160709","provider":"Iright","version":"1.0","type":"link"}