{"product_id":"abcam-ab161151","title":"Abcam, ab161151, Recombinant Human RPP29 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human RPP29 protein is a Human Fragment protein, in the 121 to 220 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:O95707,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as POP4.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRPP29 also known as ribonuclease P\/MRP subunit p29 is a protein component of the ribonuclease P complex. It has a mass of approximately 15 kDa. RPP29 is expressed ubiquitously in eukaryotic cells. It plays a mechanical role in the processing of precursor tRNA molecules cutting pre-tRNA to mature tRNA which is fundamental for protein synthesis within the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPP29 functions as an essential subunit of the ribonuclease P complex. This complex is responsible for catalyzing the maturation of pre-tRNA participating in the removal of the leader sequence from precursor tRNA molecules. It operates as part of a larger multicomponent enzyme complex on the nucleolar compartment of the cell ensuring tRNA is trimmed correctly so it can perform its function in the cellular translation machinery.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of RPP29 in the tRNA processing pathway is critical for proper protein translation. This enzyme complex including other subunits like Rpp14 and Pop1 ensures the accurate maturation of tRNA molecules which then participate in the mRNA translation pathway. Efficient processing of tRNA by the ribonuclease P complex directly influences protein biosynthesis a core cellular function that supports cell growth and proliferation.\u003cbr\u003e\nMutations or dysfunctions in the pathways involving RPP29 can lead to severe cellular consequences and are associated with certain diseases. One such condition is Dyskeratosis Congenita where defects in ribonucleoprotein complexes including the ribonuclease P complex can impact cellular integrity and function. RPP29’s role is also indirectly connected to growth retardation syndromes. Anomalies in the components of the complex like Pop1 may interfere with normal cellular homeostasis and lead to disorder manifestations.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843951448233,"sku":"ab161151","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab161151","provider":"Iright","version":"1.0","type":"link"}